Journal article
Effect of Subfornical Organ Ablation on the Development of Renal Hypertension
Clinical and experimental hypertension (1993), Vol.A6(5), pp.1027-1034
1984
DOI: 10.3109/10641968409044054
PMID: 6733941
Abstract
Both the AV3V and the SFO have been shown to mediate dipsogenic and pressor responses to angiotensin. Neuro-anatomical projections from the SFO to structures in the AV3V region have been associated with angiotensin effects. Since it has been shown that ablation of the AV3V region attenuates the development of experimental renal hypertension in rats, the effect of ablation of the SFO on the development of renal hypertension was examined. One kidney renal hypertension was produced by placing a figure of eight silk wrap around one kidney and removing the contralateral kidney. Rats with SFO lesions developed hypertension to a similar extent as rats with a sham lesion procedure. This study demonstrates that unlike the AV3V region the SFO is not critical for the development of non-renin dependent renal hypertension.
Details
- Title: Subtitle
- Effect of Subfornical Organ Ablation on the Development of Renal Hypertension
- Creators
- Mark M Knuepfer - 1Department of Pharmacology and Psychology and the Cardiovascular Center, University of Iowa, Iowa City, IA, 52242A. K Johnson - 1Department of Pharmacology and Psychology and the Cardiovascular Center, University of Iowa, Iowa City, IA, 52242M. J Brody - 1Department of Pharmacology and Psychology and the Cardiovascular Center, University of Iowa, Iowa City, IA, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.A6(5), pp.1027-1034
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641968409044054
- PMID
- 6733941
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1984
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213419702771
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