Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice

Chang Yu Kan; Jing Xuan H'ng; Andy Goh; Frederick Smales; Eng Lai Tan; Shiming Zhang; Mallikarjuna Rao Pichika; Abhishek Parolia

doi:10.1016/j.identj.2022.04.011

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Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice

Journal article

Open access

Peer reviewed

Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice

Chang Yu Kan, Jing Xuan H'ng, Andy Goh, Frederick Smales, Eng Lai Tan, Shiming Zhang, Mallikarjuna Rao Pichika and Abhishek Parolia

International dental journal, Vol.73(1), pp.63-70

02/01/2023

DOI: 10.1016/j.identj.2022.04.011

PMCID: PMC9875258

PMID: 35725589

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Abstract

This study aimed to evaluate the effect of methanol (70% v/v), ethanol (80% v/v), dimethyl sulfoxide (DMSO; 100% v/v) extracts of ginger rhizome (GR), and 6-shogaol on the pilocarpine-stimulated salivary flow rate in C57BL/6 mice. Three extracts of ginger (Zingiber officinale) rhizome prepared by maceration using the respective solvents and 6-shogoal were reconstituted in normal saline with 0.2% DMSO. Thirty C57BL/6 15-week-old mice were divided into 5 groups: Group 1, saline; Group 2, 70% methanol extract; Group 3, 80% ethanol extract; Group 4, 100% DMSO extract; and Group 5, 6-shogaol. The baseline pilocarpine-stimulated salivary flow rate was measured at the age of 15 weeks (15th week), and treatment solutions were administered by intraperitoneal injection from the 16th to 18th week. The stimulated salivary flow rate during treatment weeks was recorded for each group, and its difference with baseline was analysed using paired-sample t test. The change in salivary flow rate between the treatment groups and the control group was analysed using one-way analysis of variance. Groups 2, 3, 4, and 5 showed a significant increase in salivary flow rate when compared to baseline (P < .05). The increase in salivary flow rate in all 4 treatment groups was significant when compared to the control group (P < .05). Group 4 produced the highest increase in salivary flow rate; however, the differences amongst the treatment groups did not reach statistical significance (P > .05). All GR extracts (70% methanol, 80% ethanol, 100% DMSO) and 6-shogaol were equally effective in increasing the pilocarpine-stimulated salivary flow rate in C57BL/6 mice when administered systemically as a sustained dose for 3 weeks.

Animals

Dimethyl Sulfoxide - pharmacology

Ginger

Humans

Methanol

Mice

Mice, Inbred C57BL

Pilocarpine

Plant Extracts - pharmacology

Rhizome

Details

Title: Subtitle: Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice
Creators: Chang Yu Kan - IMU University
Jing Xuan H'ng - IMU University
Andy Goh - IMU University
Frederick Smales - IMU University
Eng Lai Tan - IMU University
Shiming Zhang - IMU University
Mallikarjuna Rao Pichika - IMU University
Abhishek Parolia - IMU University
Resource Type: Journal article
Publication Details: International dental journal, Vol.73(1), pp.63-70
DOI: 10.1016/j.identj.2022.04.011
PMID: 35725589
PMCID: PMC9875258
NLM abbreviation: Int Dent J
ISSN: 0020-6539
eISSN: 1875-595X
Grant note: DOI: 10.13039/501100009381, name: International Medical University
Language: English
Date published: 02/01/2023
Academic Unit: Endodontics
Record Identifier: 9984446428102771

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