Journal article
Effect of Topically Applied Tocopherol on Ultraviolet Radiation-Mediated Free Radical Damage in Skin
Journal of investigative dermatology, Vol.104(4), pp.484-488
04/1995
DOI: 10.1111/1523-1747.ep12605921
PMID: 7706763
Abstract
Previously, we demonstrated by electron paramagnetic resonance (EPR) spectroscopy that ultraviolet radiation induces free-radical formation in Skh-1 hairless mouse skin. Because free-radical oxidative stress is thought to play a principal role in skin photoaging and cancer, oxidative stress and subsequent photodamage should be decreased by supplementation of skin with antioxidants. Using both the ascorbate free radical and an EPR spin-trapping system to detect short-lived radicals, we evaluated the effect of the topically applied antioxidants tocopherol sorbate, α-tocopherol, and tocopherol acetate on ultraviolet radiation-induced free-radical formations. We show that tocopherol sorbate significantly decreases the ultraviolet radiation-induced radical flux in skin. With our chronically exposed mouse model, tocopherol sorbate was also found to be significantly more protective against skin photoaging than α-tocopherol and tocopherol acetate. These results extend our previous observations of ultraviolet radiation-induced free-radical generation in skin and indicate the utility of tocopherol sorbate as an antioxidant in providing significant protection against ultraviolet radiation-induced oxidative damages.
Details
- Title: Subtitle
- Effect of Topically Applied Tocopherol on Ultraviolet Radiation-Mediated Free Radical Damage in Skin
- Creators
- Beth Anne Jurkiewicz - Radiation Research Laboratory and ESR Facility, EMRB 68, University of Iowa College of Medicine, Iowa City, IowaDonald L Bissett - Procter & Gamble, Miami Valley Laboratories, Cincinnati, Ohio, USAGarry R Buettner - Radiation Research Laboratory and ESR Facility, EMRB 68, University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of investigative dermatology, Vol.104(4), pp.484-488
- Publisher
- Elsevier Inc
- DOI
- 10.1111/1523-1747.ep12605921
- PMID
- 7706763
- ISSN
- 0022-202X
- eISSN
- 1523-1747
- Language
- English
- Date published
- 04/1995
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047993402771
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