Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity

Eric P Davidson; Lawrence J Coppey; Brian Dake; Mark A Yorek

doi:10.1155/2011/686952

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Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity

Journal article

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Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity

Eric P Davidson, Lawrence J Coppey, Brian Dake and Mark A Yorek

Journal of obesity, Vol.2011, pp.1-9

2011

DOI: 10.1155/2011/686952

PMCID: PMC2933895

PMID: 20847891

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Abstract

The objective of this study was to determine the effect of AVE7688, a drug that inhibits both angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) activity, on neural and vascular defects caused by diet induced obesity (DIO). Rats at 12 weeks of age were fed a standard or high fat diet with or without AVE7688 for 24 weeks. DIO rats had impaired glucose tolerance and developed sensory neuropathy. Vascular relaxation to acetylcholine and calcitonin gene-related peptide was decreased in epineurial arterioles of DIO rats. Rats fed a high fat diet containing AVE7688 did not become obese and vascular and sensory nerve dysfunction and impaired glucose tolerance were improved. DIO is associated with increased expression of NEP in epineurial arterioles. NEP degrades vasoactive peptides which may explain the decrease in neurovascular function in DIO.

Details

Title: Subtitle: Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity
Creators: Eric P Davidson - Veteran Affairs Medical Center, Iowa City, IA 52246, USA
Lawrence J Coppey - Veteran Affairs Medical Center, Iowa City, IA 52246, USA
Brian Dake - Veteran Affairs Medical Center, Iowa City, IA 52246, USA
Mark A Yorek - Veteran Affairs Medical Center, Iowa City, IA 52246, USA
Resource Type: Journal article
Publication Details: Journal of obesity, Vol.2011, pp.1-9
DOI: 10.1155/2011/686952
PMID: 20847891
PMCID: PMC2933895
NLM abbreviation: J Obes
ISSN: 2090-0708
eISSN: 2090-0716
Publisher: Hindawi Publishing Corporation
Grant note: DOI: 10.13039/100000738, name: Department of Veterans Affairs, award: DK073990
Language: English
Date published: 2011
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984094770202771

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