Journal article
Effect of Varying Fibrinogen and Hematocrit Concentrations on Magnetic Resonance Relaxation Times of Thrombus
Investigative radiology, Vol.27(5), pp.341-345
05/1992
DOI: 10.1097/00004424-199205000-00003
PMID: 1582815
Abstract
OBJECTIVES.The authors assessed the effects of varying one extracellular component (fibrinogen concentration) and one cellular component (hematocrit) on magnetic resonance (MR) T1 and T2 relaxation times of in vitro blood clots.
METHODS.Blood from six male subjects was collected into sodium citrate anticoagulant (3.8%) and the whole blood was separated into platelet-rich plasma and packed erythrocytes. Subsequently, in vitro blood clots were made from varying concentrations of fibrinogen (1, 10, and 100 µM) in Tyrodeʼs solution and washed, packed erythrocytes (hematocrit levels0%, 10%, 40%, and 80%). T1 and T2 measurements were completed at 20 MHz within 8 hours of initiating clotting.
RESULTS.Significant shortening of MR relaxation times occurred with increasing fibrinogen concentration for hematocrit values of 0% and 10%. Extracellular fibrinogen concentration did not contribute significantly to variation in relaxation times at hematocrit values of 40% and 80%. For any given fibrinogen level, significant shortening occurred in T1 and T2 values for each successive increase in hematocrit values.
CONCLUSIONS.Both extracellular (fibrinogen) and cellular (erythrocyte concentration) factors are significant determinants of thrombus T1 and T2 relaxation times.
Details
- Title: Subtitle
- Effect of Varying Fibrinogen and Hematocrit Concentrations on Magnetic Resonance Relaxation Times of Thrombus
- Creators
- JOHN Stuhlmuller - University of IowaJOHN Olson - University of IowaTRUDY Burns - University of IowaDAVID Skorton - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.27(5), pp.341-345
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00004424-199205000-00003
- PMID
- 1582815
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Language
- English
- Date published
- 05/1992
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364399702771
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