Effect of a reduced donor heart right ventricular distensibility on post-heart transplant haemodynamics

Yuki Nakamura; Daisuke Yoshioka; Hidetsugu Asanoi; Shigeru Miyagawa; Yasushi Yoshikawa; Hiroki Hata; Ryoto Sakaniwa; Koichi Toda; Yoshiki Sawa

doi:10.1093/icvts/ivaa222

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Effect of a reduced donor heart right ventricular distensibility on post-heart transplant haemodynamics

Journal article

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Effect of a reduced donor heart right ventricular distensibility on post-heart transplant haemodynamics

Yuki Nakamura, Daisuke Yoshioka, Hidetsugu Asanoi, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Ryoto Sakaniwa, Koichi Toda and Yoshiki Sawa

Interactive cardiovascular and thoracic surgery, Vol.32(1), pp.141-149

01/01/2021

DOI: 10.1093/icvts/ivaa222

PMID: 33232450

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Abstract

OBJECTIVES This study aimed to investigate the characteristics of a reduced right ventricular distensibility after heart transplant. METHODS This study enrolled 64 adult patients who underwent heart transplant at our institution. The degree of right ventricular distensibility was quantified by calculating the difference between right atrial pressures (RAPs) of X descent and Y descent (X–Y) from the RAP waveform in right heart catheterization. Histologically, the ratio of the interstitial tissue in myocardial biopsy samples was calculated. RESULTS Of the 64 patients, 35 (55%) had a reduced right ventricular distensibility at 1 week after heart transplant (X–Y > 1 mmHg, RD group), and 29 (45%) had a normal right ventricular distensibility (X–Y ≤ 1 mmHg, ND group). The mean RAP and mean pulmonary capillary wedge pressure 1 week after heart transplant in the RD group were significantly higher than that in the ND group. The mean RAP and mean pulmonary capillary wedge pressure in the RD group gradually normalized 12 weeks postoperation. The ratio of the interstitial tissue of biopsy samples significantly correlated with the X–Y value. The number of patients who required inotropic support >14 days was higher in the RD group than in the ND group. CONCLUSIONS Reduced donor heart distensibility was a common impairment early after heart transplant. It might result from interstitial oedema in the myocardial tissue of the donor heart. Reduced donor heart distensibility after heart transplant might be associated with early clinical outcomes; however, further investigation is required.

Donor heart

Haemodynamics

Heart transplant

Ventricular distensibility

Details

Title: Subtitle: Effect of a reduced donor heart right ventricular distensibility on post-heart transplant haemodynamics
Creators: Yuki Nakamura - The University of Osaka
Daisuke Yoshioka - The University of Osaka
Hidetsugu Asanoi - The University of Osaka
Shigeru Miyagawa - The University of Osaka
Yasushi Yoshikawa - The University of Osaka
Hiroki Hata - The University of Osaka
Ryoto Sakaniwa - The University of Osaka
Koichi Toda - The University of Osaka
Yoshiki Sawa - The University of Osaka
Resource Type: Journal article
Publication Details: Interactive cardiovascular and thoracic surgery, Vol.32(1), pp.141-149
DOI: 10.1093/icvts/ivaa222
PMID: 33232450
ISSN: 1569-9293
eISSN: 1569-9285
Publisher: Oxford University Press
Number of pages: 9
Language: English
Date published: 01/01/2021
Academic Unit: Cardiothoracic Surgery
Record Identifier: 9985164037302771

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