Journal article
Effect of a single dose of esmolol on the bispectral index to endotracheal intubation during desflurane anesthesia
Korean journal of anesthesiology, Vol.64(5), pp.420-425
05/01/2013
DOI: 10.4097/kjae.2013.64.5.420
PMCID: PMC3668103
PMID: 23741564
Abstract
Background: In this prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of a single dose of esmolol on the bispectral index (BIS) to endotracheal intubation during desflurane anesthesia.
Methods: After induction of anesthesia, 60 patients were mask-ventilated with desflurane (end-tidal 1 minimum alveolar concentration) for 5 min and then received either normal saline, esmolol 0.5 or 1 mg/kg, 1 min prior to intubation (control, esmolol-0.5 and esmolol-1 groups, n = 20/group). BIS, mean arterial pressure, and heart rate were measured prior to anesthesia induction and esmolol administration, immediately preceding intubation (time point 0), and every minute for 5 min after intubation (time point 1 to 5). At time point 0, 1 and 5, 5 ml of arterial blood was taken to measure plasma concentrations of norepinephrine and epinephrine.
Results: BIS increased significantly at 1 min after intubation when compared with pre-intubation values in all groups. Both mean arterial pressure and heart rate increased significantly 1 min after intubation when compared with preintubation values for all groups. Plasma epinephrine concentrations did not increase significantly after tracheal intubation in any of the groups. Norepinephrine increased at 1 min after intubation when compared with the preintubation values in the esmolol groups (P < 0.05).
Conclusions: A single bolus of esmolol was unable to blunt the increase in BIS to endotracheal intubation during desflurane anesthesia.
Details
- Title: Subtitle
- Effect of a single dose of esmolol on the bispectral index to endotracheal intubation during desflurane anesthesia
- Creators
- Eun Mi Choi - Hallym UniversityKyeong Tae Min - Yonsei UniversityJeong Rim Lee - Yonsei UniversityTai Kyung Lee - Yonsei UniversitySeung Ho Choi - Yonsei University
- Resource Type
- Journal article
- Publication Details
- Korean journal of anesthesiology, Vol.64(5), pp.420-425
- DOI
- 10.4097/kjae.2013.64.5.420
- PMID
- 23741564
- PMCID
- PMC3668103
- NLM abbreviation
- Korean J Anesthesiol
- ISSN
- 2005-6419
- eISSN
- 2005-7563
- Publisher
- Korean Soc Anesthesiologists
- Number of pages
- 6
- Language
- English
- Date published
- 05/01/2013
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806513602771
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