Effect of a single ethanol exposure on HIV replication in human lymphocytes

R T Cook; J T Stapleton; Z K Ballas; D Klinzman

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Effect of a single ethanol exposure on HIV replication in human lymphocytes

Journal article

Peer reviewed

Effect of a single ethanol exposure on HIV replication in human lymphocytes

R T Cook, J T Stapleton, Z K Ballas and D Klinzman

Journal of investigative medicine, Vol.45(5), pp.265-271

06/1997

PMID: 9249999

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Abstract

Alcoholism is known to cause perturbations in cellular and humoral immunity, and some data suggest that acute alcohol ingestion enhances HIV replication in the lymphocytes of drinkers. To study the acute effects of alcohol ingestion on HIV replication, oral ethanol (1 g/kg) was administered to 12 healthy volunteers in a controlled clinical setting. In vitro replication of HIV in the subjects' cultured lymphocytes and changes in lymphocyte phenotypes were evaluated. Statistically significant increases in peripheral lymphocytes and natural killer cell numbers were identified after the initial ethanol trial. HIV replication also increased in the isolated lymphocytes of some subjects after ethanol ingestion, but most subjects in the second trial showed essentially no changes in any of these parameters. Our results are consistent with either a subtle, study-induced stress-related enhancement in HIV replication or significant individual variation in response to ethanol. The results do not provide evidence for a general increase in HIV replication in the lymphocytes of subjects following a single in vivo ethanol dose of 1 g/kg.

Virus Replication - drug effects

Ethanol - pharmacology

Ethanol - blood

HIV - physiology

Humans

Adult

Female

Male

In Vitro Techniques

Leukocytes, Mononuclear - virology

HIV - drug effects

Details

Title: Subtitle: Effect of a single ethanol exposure on HIV replication in human lymphocytes
Creators: R T Cook - Department of Pathology, Veterans Affairs Medical Center, Iowa City, IA 52246, USA
J T Stapleton
Z K Ballas
D Klinzman
Resource Type: Journal article
Publication Details: Journal of investigative medicine, Vol.45(5), pp.265-271
PMID: 9249999
ISSN: 1081-5589
eISSN: 1708-8267
Grant note: RR0059 / NCRR NIH HHS 1 RO1-AA-09598 / NIAAA NIH HHS 5 UO1-AI-27661-10 / NIAID NIH HHS
Language: English
Date published: 06/1997
Academic Unit: Microbiology and Immunology; Infectious Diseases; Pathology; Immunology; Internal Medicine
Record Identifier: 9984094614102771

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34 Times Cited - Web of Science