Effect of accessibility of a genetic counselor on uptake of preimplantation genetic testing for aneuploidy (PGT-A) and carrier screening for patients undergoing in vitro fertilization

Prapti Singh; Caitlin E Martin; Erica Jamro-Comer; Marisa V Andrews; Alison Almgren-Bell; Joan Riley; Patricia T Jimenez

doi:10.1002/jgc4.1701

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Effect of accessibility of a genetic counselor on uptake of preimplantation genetic testing for aneuploidy (PGT-A) and carrier screening for patients undergoing in vitro fertilization

Journal article

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Effect of accessibility of a genetic counselor on uptake of preimplantation genetic testing for aneuploidy (PGT-A) and carrier screening for patients undergoing in vitro fertilization

Prapti Singh, Caitlin E Martin, Erica Jamro-Comer, Marisa V Andrews, Alison Almgren-Bell, Joan Riley and Patricia T Jimenez

Journal of genetic counseling, Vol.32(4), pp.906-915

04/11/2023

DOI: 10.1002/jgc4.1701

PMID: 37042036

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Abstract

This retrospective cohort study assessed the accessibility of a genetic counselor on uptake of preimplantation genetic testing for aneuploidy (PGT-A) and carrier screening in a single academic Reproductive Endocrinology and Infertility (REI) clinic. A total of 420 patients were evaluated with 219 patients counseled by a REI physician only and 201 patients after the addition of a genetic counselor (GC) to the REI clinic team. Cycles initiated before hiring of a GC (pre-GC) were assessed from June 2018 to December 2018 and after integration of a GC (post-GC) from March 2019 to August 2019. Additionally, information regarding carrier screening was collected if available in the medical record. Results showed more patients utilized PGT-A post-GC (9.5% vs. 5.5%), although the difference between groups did not reach statistical significance (p = 0.12). Individuals who were screened post-GC or who started screening pre-GC and continued screening post-GC were screened for a larger number of conditions than if they were only screened pre-GC (median pre-GC = 3, post-GC = 27, pre- and post-GC = 274; p < 0.0001). The change in practice from using physician-only counseling to counseling with accessibility to a GC did not change the utilization of PGT-A in a single clinic.

genetic counseling

preimplantation genetic testing for aneuploidy (PGT-A)

carrier screening

genetic counselors

UIOWA OA Agreement

Details

Title: Subtitle: Effect of accessibility of a genetic counselor on uptake of preimplantation genetic testing for aneuploidy (PGT-A) and carrier screening for patients undergoing in vitro fertilization
Creators: Prapti Singh - Washington University in St. Louis
Caitlin E Martin - Department of Obstetrics and Gynecology, Fertility and Reproductive Medicine Center, St. Louis, Missouri, USA
Erica Jamro-Comer - Washington University in St. Louis
Marisa V Andrews - Department of Obstetrics and Gynecology, Fertility and Reproductive Medicine Center, St. Louis, Missouri, USA
Alison Almgren-Bell - Washington University in St. Louis
Joan Riley - Division of Reproductive Endocrinology and Infertility, Feinberg School of Medicine, Chicago, Illinois, USA
Patricia T Jimenez - Department of Obstetrics and Gynecology, Fertility and Reproductive Medicine Center, St. Louis, Missouri, USA
Resource Type: Journal article
Publication Details: Journal of genetic counseling, Vol.32(4), pp.906-915
DOI: 10.1002/jgc4.1701
PMID: 37042036
NLM abbreviation: J Genet Couns
eISSN: 1573-3599
Publisher: Wiley
Language: English
Date published: 04/11/2023
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984397449502771

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