Journal article
Effect of acute intravascular volume expansion on human fetal prostaglandin concentrations
American journal of obstetrics and gynecology, Vol.161(6), pp.1494-1497
12/01/1989
DOI: 10.1016/0002-9378(89)90911-3
PMID: 2513719
Abstract
Direct fetal intravascular transfusion is well tolerated by the human fetus. However, the rapid transfusion of high-hematocrit blood should increase vessel distention and the flow shear force. Each is known to stimulate the release of prostacyclin. We measured prostaglandins E
2 and F
2α and the stable metabolite of prpstacyclin, 6-keto-prostaglandin F
1α, by radioimmunoassay before, at the estimated midway point of, and at the completion of 40 umbilical venous transfusions performed because of immune hemolytic anemia. Umbilical venous pressures corrected for amniotic fluid pressure were measured at similar intervals during nine of the procedures. The mean (±SEM) length of gestation at transfusion was 29 ± 1 week, opening hematocrit 23% ± 1%, and total volume of 70% hematocrit red blood cells transfused 83 ± 5 ml. 6-Keto-prostaglandin, F
1α was the principal circulating fetal prostanoid and its concentration was unrelated to gestational age. Intravenous transfusion was associated with an 84% increase in 6-keto-prostaglandin F
1α (
p = 0.03) and a 68% increase in prostaglandin E
2 (
p < 0.05). The rise for each strongly correlated with the rise in the fetal umbilical venous pressure (6-keto-prostaglandin F
1α,
r = 0.94,
p = 0.0005; prostaglandin E
2,
r = 0.81,
p < 0.03). We conclude that 6-keto-prostaglandin F
1α is the principal circulating prpstaglandin in the human fetus and that the release of venodilator prostaglandins may be one reason the human fetus can tolerate a large increase in intravascular volume without obvious sequelae.
Details
- Title: Subtitle
- Effect of acute intravascular volume expansion on human fetal prostaglandin concentrations
- Creators
- Carl P. Weiner - University of IowaJean E. Robillard - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.161(6), pp.1494-1497
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-9378(89)90911-3
- PMID
- 2513719
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Number of pages
- 4
- Language
- English
- Date published
- 12/01/1989
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773399002771
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