Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users

Laura L Boles Ponto; Daniel S O'Leary; Julie Koeppel; Robert I Block; G Leonard Watkins; John C W Richmond; Christine A Ward; Dean A Clermont; Beth A Schmitt; Richard D Hichwa

doi:10.1177/0091270004265699

Back

Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users

Journal article

Peer reviewed

Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users

Laura L Boles Ponto, Daniel S O'Leary, Julie Koeppel, Robert I Block, G Leonard Watkins, John C W Richmond, Christine A Ward, Dean A Clermont, Beth A Schmitt and Richard D Hichwa

Journal of clinical pharmacology, Vol.44(7), pp.751-766

07/2004

DOI: 10.1177/0091270004265699

PMID: 15199080

View Online

Abstract

The objective of this study was to evaluate the effect of the acute administration of marijuana (MJ) on cardiovascular (CV) function and CNS pharmacokinetics (PK) of [(15)O]water in occasional (O) versus chronic (C) MJ users. Each subject received four injections of [(15)O]water (one prior and three postsmoking) on two occasions in which they received active or placebo MJ. For each injection, measures of CV function and CNS PK [(15)O]water were made. Postsmoking, MJ influenced all measured CV and [(15)O]water PK parameters. C users reported significantly lower "highness" and smaller heart rate (HR) changes, which resulted in reduced rate pressure product (RPP) changes compared to O users, even though Delta(9)-tetrahydrocannabinol levels were higher, whereas changes in blood pressure (BP), arrival time, and [(15)O]water concentration were not significantly different between the groups. Significant CV changes resulted in changes in the whole-body distribution of cardiac output rather than changes in cerebral blood flow. Chronic MJ use produces tolerance to the HR increases induced by acute MJ smoking compared to changes observed in occasional users, without changing the effects on BP and [(15)O]water PK.

Marijuana Smoking - adverse effects

Central Nervous System - metabolism

Oxygen Radioisotopes

Humans

Drug Tolerance

Water - metabolism

Male

Cardiovascular System - drug effects

Dronabinol - blood

Heart Rate - drug effects

Drug Interactions

Adult

Female

Blood Pressure - drug effects

Tomography, Emission-Computed

Details

Title: Subtitle: Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users
Creators: Laura L Boles Ponto - PET Imaging Center, 0911 Z JPP, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
Daniel S O'Leary
Julie Koeppel
Robert I Block
G Leonard Watkins
John C W Richmond
Christine A Ward
Dean A Clermont
Beth A Schmitt
Richard D Hichwa
Resource Type: Journal article
Publication Details: Journal of clinical pharmacology, Vol.44(7), pp.751-766
DOI: 10.1177/0091270004265699
PMID: 15199080
NLM abbreviation: J Clin Pharmacol
ISSN: 0091-2700
eISSN: 1552-4604
Publisher: England
Grant note: R01 DA10551 / NIDA NIH HHS
Language: English
Date published: 07/2004
Academic Unit: Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Anesthesia
Record Identifier: 9984003973202771

Metrics

14 Record Views

29 Times Cited - Web of Science