Journal article
Effect of age and socioeconomic factors in the utilization of chemotherapy in Acute Lymphoblastic Leukemia (ALL): A SEER database study of 16,196 patients
Clinical lymphoma, myeloma and leukemia, Vol.22(10), pp.E907-E914
10/01/2022
DOI: 10.1016/j.clml.2022.06.006
PMID: 35811282
Abstract
: Use of chemotherapy in ALL patients was assessed in real-world setting. Using the SEER database, we analyzed data of 16,196 patients diagnosed with ALL from 2006 to 2016. Utilization of chemotherapy decreased with advancing age. Additionally, single or widowed status, lower educational status, and lack of insurance were associated with lower receipt of chemotherapy.
: The use of multiagent chemotherapy in acute lymphoblastic leukemia (ALL) has resulted in improvement in overall survival (OS), albeit to a different extent across various age groups. This large database study aims to assess the disparity in the utilization of chemotherapy in ALL in the real-world setting.
: Using the Surveillance, Epidemiology, and End Results database, patients with ALL diagnosis from 2006 to 2016 were identified. Baseline characteristics were compared between the groups who did versus did not receive chemotherapy using χ2 test. Multivariable logistic regression was used to evaluate the association between various sociodemographic factors and the receipt of chemotherapy in the entire cohort and in different age groups.
: Out of 16,196 patients, 1258 patients (8%) did not receive chemotherapy. There was a steady increase in the number of patients who did not receive chemotherapy with advancing age- 2.5% (0-18 years), 5.2% (19-40 years), 9.3% (41-65 years), and 36.2% (>65 years). There was an upward trend in the receipt of chemotherapy in patients >65 years over the last decade. In multivariate analysis, the likelihood of receiving chemotherapy decreased with advancing age, single or widowed status, low income and educational status, and lack of insurance. Insurance status was an independent predictor of receipt of chemotherapy across each age category.
: A significant proportion of patients >65 years do not receive chemotherapy in the United States. Age, marital status, income, education, and insurance status contribute to the disparity in utilization of chemotherapy.
Details
- Title: Subtitle
- Effect of age and socioeconomic factors in the utilization of chemotherapy in Acute Lymphoblastic Leukemia (ALL): A SEER database study of 16,196 patients
- Creators
- Utsav Joshi - Rochester General HospitalAnurag Adhikari - Jacobi Medical CenterUttam Bhetuwal - Rhode Island HospitalAdheesh Bhattarai - Tribhuvan University Teaching HospitalVishakha Agrawal - Tribhuvan University Teaching HospitalShristi Upadhyay Banskota - University of Nebraska Medical CenterPrajwal Dhakal - University of IowaVijaya Raj Bhatt - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Clinical lymphoma, myeloma and leukemia, Vol.22(10), pp.E907-E914
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.clml.2022.06.006
- PMID
- 35811282
- ISSN
- 2152-2650
- eISSN
- 2152-2669
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359836802771
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