Journal article
Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography
Investigative ophthalmology & visual science, Vol.54(7), pp.4934-4940
07/22/2013
DOI: 10.1167/iovs.13-11913
PMCID: PMC5963176
PMID: 23761080
Abstract
To determine the effect of age on the thickness of individual retinal layers, measured with spectral-domain optical coherence tomography (SD-OCT), in a population of healthy Caucasians. One hundred and twenty subjects with an age ranging between 18 and 81 years were examined with SD-OCT. Mean layer thickness was calculated for seven retinal layers, in the fovea (region 1 of the 9 Early Treatment Diabetic Retinopathy Study [ETDRS] regions); in the pericentral ring (ETDRS regions 2 to 5); and the peripheral ring (ETDRS regions 6 to 9) following automated segmentation using the Iowa Reference Algorithm. In addition, mean peripapillary retinal nerve fiber layer (RNFL) thickness was measured. The partial correlation test was performed on each layer to determine the effect of age on layer thickness, while correcting for spherical equivalent, sex, and Topcon image quality factor as confounders, followed by Bonferroni corrections to adjust for multiple testing. The thickness of the peripapillary RNFL (R = -0.332; P < 0.001); pericentral ganglion cell layer (R = -0.354, P < 0.001); peripheral inner plexiform layer (R = -0.328, P < 0.001); and foveal outer segment layer (R = -0.381, P < 0.001) decreased significantly with increasing age. Foveal RPE thickness (R = 0.467, P < 0.001) increased significantly with increasing age; other layers showed no significant differences with age. Several macular layers and the peripapillary RNFL thickness showed significant changes correlated with age. This should be taken into consideration when analyzing macular layers and the peripapillary RNFL in SD-OCT studies of retinal diseases and glaucoma.
Details
- Title: Subtitle
- Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography
- Creators
- Nazli Demirkaya - Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. NDemirkaya@amc.nlHille W van DijkSanne M van SchuppenMichael D AbràmoffMona K GarvinMilan SonkaReinier O SchlingemannFrank D Verbraak
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.54(7), pp.4934-4940
- DOI
- 10.1167/iovs.13-11913
- PMID
- 23761080
- PMCID
- PMC5963176
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- R01 EY019112 / NEI NIH HHS R01 EB004640 / NIBIB NIH HHS R01 EY018853 / NEI NIH HHS
- Language
- English
- Date published
- 07/22/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983806390402771
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