Journal article
Effect of alcohol in traumatic brain injury: is it really protective?
The Journal of surgical research, Vol.190(2), pp.634-639
08/01/2014
DOI: 10.1016/j.jss.2014.04.039
PMID: 24857283
Abstract
Studies have proposed a neuroprotective role for alcohol (ETOH) in traumatic brain injury (TBI). We hypothesized that ETOH intoxication is associated with mortality in patients with severe TBI.
Version 7.2 of the National Trauma Data Bank (2007-2010) was queried for all patients with isolated blunt severe TBI (Head Abbreviated Injury Score ≥4) and blood ETOH levels recorded on admission. Primary outcome measure was mortality. Multivariate logistic regression analysis was performed to assess factors predicting mortality and in-hospital complications.
A total of 23,983 patients with severe TBI were evaluated of which 22.8% (n = 5461) patients tested positive for ETOH intoxication. ETOH-positive patients were more likely to have in-hospital complications (P = 0.001) and have a higher mortality rate (P = 0.01). ETOH intoxication was an independent predictor for mortality (odds ratio: 1.2, 95% confidence interval: 1.1-2.1, P = 0.01) and development of in-hospital complications (odds ratio: 1.3, 95% confidence interval: 1.1-2.8, P = 0.009) in patients with isolated severe TBI.
ETOH intoxication is an independent predictor for mortality in patients with severe TBI patients and is associated with higher complication rates. Our results from the National Trauma Data Standards differ from those previously reported. The proposed neuroprotective role of ETOH needs further clarification.
Details
- Title: Subtitle
- Effect of alcohol in traumatic brain injury: is it really protective?
- Creators
- Viraj Pandit - University of ArizonaNikita Patel - University of ArizonaPeter Rhee - University of ArizonaNarong Kulvatunyou - University of ArizonaHassan Aziz - University of ArizonaDonald J Green - University of ArizonaTerence O'Keeffe - University of ArizonaBardiya Zangbar - University of ArizonaAndrew Tang - University of ArizonaLynn Gries - University of ArizonaRandall S Friese - University of ArizonaBellal Joseph - University of Arizona
- Resource Type
- Journal article
- Publication Details
- The Journal of surgical research, Vol.190(2), pp.634-639
- DOI
- 10.1016/j.jss.2014.04.039
- PMID
- 24857283
- ISSN
- 0022-4804
- eISSN
- 1095-8673
- Language
- English
- Date published
- 08/01/2014
- Academic Unit
- Surgery
- Record Identifier
- 9984701556102771
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