Journal article
Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings
Physiological reports, Vol.8(19), pp.e14603-n/a
10/10/2020
DOI: 10.14814/phy2.14603
PMCID: PMC7547589
PMID: 33038073
Abstract
CFTR‐mediated chloride conductance in airway epithelia is commonly analyzed in the presence of a chloride gradient, which increases CFTR‐mediated changes in potential difference and transepithelial current. This study demonstrates that the presence of a chloride gradient can impact measurements of responses of CF epithelial to CFTR modulation in vitro.
Details
- Title: Subtitle
- Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings
- Creators
- Preston E. Bratcher - University of Colorado Anschutz Medical CampusSangya Yadav - National Jewish HealthCiaran A. Shaughnessy - National Jewish HealthIan M. Thornell - University of IowaPamela L. Zeitlin - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- Physiological reports, Vol.8(19), pp.e14603-n/a
- DOI
- 10.14814/phy2.14603
- PMID
- 33038073
- PMCID
- PMC7547589
- NLM abbreviation
- Physiol Rep
- ISSN
- 2051-817X
- eISSN
- 2051-817X
- Publisher
- John Wiley and Sons Inc
- Grant note
- BRATCH16I0 / ; Eugene F. and Easton M. Crawford Charitable Lead Unitrust Gilead Sciences Research Scholars Program in Cystic Fibrosis
- Alternative title
- BRATCHER et al
- Language
- English
- Date published
- 10/10/2020
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359781302771
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