Journal article
Effect of atherosclerosis on cerebral vascular responses to activation of leukocytes and platelets in monkeys
Stroke (1970), Vol.22(6), pp.790-796
06/1991
DOI: 10.1161/01.STR.22.6.790
PMID: 2057980
Abstract
The goal of this study was to test the hypothesis that atherosclerosis alters responses of cerebral arteries and the ocular circulation to the activation in vivo of leukocytes and platelets. We measured blood flow to the brain and eye using microspheres and pressure in the cerebral microvessels of normal and atherosclerotic monkeys. The intracarotid injection of 10(-7) M N-formyl-L-methionyl-L-leucyl-L-phenylalanine to activate leukocytes did not alter cerebral blood flow in 11 normal or 10 atherosclerotic monkeys but increased the resistance of large cerebral arteries by 46 +/- 11% (mean +/- SEM) in the atherosclerotic animals. The injection of N-formyl-L-methionyl-L-leucyl-L-phenylalanine did not alter blood flow to the eye in 10 normal monkeys but decreased blood flow to the choroid by 38 +/- 9% in 11 atherosclerotic monkeys. The intracarotid injection of 3 x 10(-9) M prostaglandin E2, a leukocyte product, produced an increase in the resistance of large cerebral arteries in five atherosclerotic but not in six normal monkeys. Prostaglandin E2 reduced blood flow to the retina and choroid in the atherosclerotic monkeys by 62 +/- 22% and 65 +/- 17%, respectively. The intracarotid infusion of 25 micrograms/min collagen to activate platelets increased cerebral blood flow by 21 +/- 5% in 10 normal monkeys but did not alter it in 11 atherosclerotic monkeys. Collagen did not alter blood flow to the choroid in 10 normal monkeys but decreased it by 29 +/- 8% in 11 atherosclerotic monkeys.
Details
- Title: Subtitle
- Effect of atherosclerosis on cerebral vascular responses to activation of leukocytes and platelets in monkeys
- Creators
- F M Faraci - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, IowaA G LopezK BreeseM L ArmstrongD D Heistad
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.22(6), pp.790-796
- Publisher
- United States
- DOI
- 10.1161/01.STR.22.6.790
- PMID
- 2057980
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Grant note
- HL-16066 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
- Language
- English
- Date published
- 06/1991
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040372702771
Metrics
20 Record Views