Effect of atriopeptin on blood flow to cerebrum and choroid plexus

Kimberly A Schalk; John L Williams; Donald D Heistad

doi:10.1152/ajpregu.1989.257.6.R1365

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Effect of atriopeptin on blood flow to cerebrum and choroid plexus

Journal article

Peer reviewed

Effect of atriopeptin on blood flow to cerebrum and choroid plexus

Kimberly A Schalk, John L Williams and Donald D Heistad

The American journal of physiology, Vol.257(6 Pt 2), pp.R1365-1369

12/1989

DOI: 10.1152/ajpregu.1989.257.6.R1365

PMID: 2532479

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Abstract

The goal of this study was to determine whether atriopeptin alters blood flow to cerebrum and choroid plexus. In anesthetized rabbits, blood flow (microspheres) to cerebrum and choroid plexus under control conditions was 36 +/- 3 (mean +/- SE) and 573 +/- 78 ml.min-1.100 g-1, respectively. Infusion of atriopeptin (75, 225, 1,150 ng.kg-1.min-1 iv) increased blood flow to choroid plexus by 22 +/- 11, 53 +/- 26, and 51 +/- 13%, respectively. In contrast, blood flow to cerebrum was not altered by atriopeptin, presumably because the blood-brain barrier prevented access to cerebral vascular smooth muscle. Because a major role of atriopeptin may be to modulate responses to angiotensin II, we examined effects of atriopeptin on vasoconstrictor responses to angiotensin II in the choroid plexus. Angiotensin II was infused in the presence or absence of atriopeptin (300 ng.kg-1.min-1 iv). Angiotensin II (100 ng.kg-1.min-1 iv) decreased blood flow to choroid plexus by 49 +/- 12% and by 47 +/- 14% during simultaneous infusion of atriopeptin. In summary, atriopeptin 1) increases blood flow to choroid plexus, but not cerebrum, and 2) does not appear to attenuate vasoconstrictor effects of angiotensin II in the choroid plexus.

Rabbits

Cerebrovascular Circulation - drug effects

Atrial Natriuretic Factor - blood

Carbon Dioxide - blood

Oxygen - blood

Brain - blood supply

Choroid Plexus - blood supply

Animals

Regional Blood Flow - drug effects

Partial Pressure

Renal Circulation - drug effects

Blood Pressure - drug effects

Atrial Natriuretic Factor - pharmacology

Intestines - blood supply

Hydrogen-Ion Concentration

Details

Title: Subtitle: Effect of atriopeptin on blood flow to cerebrum and choroid plexus
Creators: Kimberly A Schalk - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
John L Williams
Donald D Heistad
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.257(6 Pt 2), pp.R1365-1369
Publisher: United States
DOI: 10.1152/ajpregu.1989.257.6.R1365
PMID: 2532479
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-16066 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS HL-14388 / NHLBI NIH HHS
Language: English
Date published: 12/1989
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040588202771

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