Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

D Heistad; F M Abboud; A L Mark; P G Schmid

doi:10.1152/jappl.1975.39.3.411

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Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

Journal article

Peer reviewed

Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

D Heistad, F M Abboud, A L Mark and P G Schmid

Journal of applied physiology (1948), Vol.39(3), pp.411-416

09/1975

DOI: 10.1152/jappl.1975.39.3.411

PMID: 1176408

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Abstract

This study tested the hypothesis that ventilatory responses to chemoreceptor stimulation are affected by the level of arterial pressure and degree of baroreceptor activation. Carotid chemoreceptors were stimulated by injection of nicotine into the common carotid artery of anesthetized dogs. Arterial pressure was reduced by bleeding the animals and raised by transient occlusion of the abdominal aorta. The results indicate that ventilatory responses to chemoreceptor stimulation were augmented by hypotension and depressed by hypertension. In additional studies we excluded the possibility that the findings were produced by a direct effect of changes in arterial pressure on chemoreceptors. Both carotid bifurcations were perfused at constant flow. In one carotid bifurcation, perfusion pressure was raised to stimulate carotid sinus baroreceptors. In the other carotid bifurcation, pressure was constant and nicotine was injected to stimulate carotid chemoreceptors. Stimulation of baroreceptors on one side attenuated the ventilatory response to stimulation of contralateral chemoreceptors. This inhibition was observed before and after bilateral cervical vagotomy. We conclude that there is a major central interaction between baroreceptor and chemoreceptor reflexes so that changes in baroreceptor activity modulate ventilatory responses to chemoreceptor stimulation.

Blood Pressure

Carotid Body - physiology

Chemoreceptor Cells - drug effects

Hyperventilation - chemically induced

Pressoreceptors - physiology

Carotid Sinus - physiology

Stimulation, Chemical

Vagotomy

Hypertension - physiopathology

Nicotine - pharmacology

Animals

Hypotension - physiopathology

Respiration - drug effects

Dogs

Carotid Body - drug effects

Carotid Sinus - drug effects

Details

Title: Subtitle: Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation
Creators: D Heistad
F M Abboud
A L Mark
P G Schmid
Resource Type: Journal article
Publication Details: Journal of applied physiology (1948), Vol.39(3), pp.411-416
Publisher: United States
DOI: 10.1152/jappl.1975.39.3.411
PMID: 1176408
ISSN: 0021-8987
eISSN: 2691-2473
Language: English
Date published: 09/1975
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984025475302771

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