Journal article
Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects
The American heart journal, Vol.105(5), pp.777-782
05/1983
DOI: 10.1016/0002-8703(83)90240-5
PMID: 6303097
Abstract
We investigated the effects of beta-adrenergic blockade with propranolol (P) on circulating catecholamines at rest and during isometric and dynamic exercise. By means of a radioenzymatic assay, we measured plasma norepinephrine (NE) and epinephrine (E) concentrations in nine normal, sedentary men, aged 22 to 34 years. Measurements were made during resting conditions, at 3 minutes of 30% maximal isometric handgrip exercise (IHE), and during submaximal and maximal dynamic treadmill exercise. Measurements were repeated one week later after the subjects received P in doses ranging from 40 to 80 mg four times a day (plasma P levels at the time of exercise ranged from 96 to 303 ng/ml with a mean of 178 ng/ml). We also measured serum dopamine-beta-hydroxylase (DBH) activity to detect changes in chronic sympathetic tone. Changes in NE from rest to exercise were significant (
p < 0.01) at all exercise loads with or without P. Changes in E from rest to exercise were significant (
p < 0.01) at all exercise loads with or without P except for submaximal dynamic exercise during the control study (
p > 0.05). For NE, there were no significant differences between the control and P values either at rest or during any form of exercise. For E, there were no significant changes between the control and
p values at rest or at maximal dynamic exercise, although there were mild increases (
p < 0.05) with IHE and submaximal dynamic exercise. DBH activity increased significantly (
p < 0.01) from rest to exercise for all exercise points with and without P, but there were no significant differences between the control and
p values either at rest or during any form of exercise. In conclusion, we have demonstrated that competitive blockade of beta-adrenergic receptors at the tissue level does not alter neural release of NE or DBH and has little effect on adrenal release of E.
Details
- Title: Subtitle
- Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects
- Creators
- Mark W. Sheehan - University of Colorado HealthH.L. Brammell - University of Colorado HealthDavid L. Sable - University of Colorado HealthAlan S. Nies - University of Colorado HealthLawrence D. Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.105(5), pp.777-782
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-8703(83)90240-5
- PMID
- 6303097
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 05/1983
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656531402771
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