Journal article
Effect of beta-adrenergic blockade on left ventricular function in exercise
The American journal of physiology, Vol.227(4), pp.839-842
10/1974
DOI: 10.1152/ajplegacy.1974.227.4.839
PMID: 4429132
Abstract
The effect of beta-adrenergic blockade with propranolol on left ventricular diameter during exercise was investigated in dogs running on a treadmill. Cardiac output was substantially reduced by propranolol at all levels of exercise. Stroke volume was reduced by 22, 27, and 23% for mild, moderate, and severe exercise, respectively, due to elevations in left ventricular end-systolic dimensions. During mild and moderate exercise, the Frank-Starling mechanism compensated partially for the loss of the sympathetic inotropic and chronotropic effects. However, during severe exercise there were no significant differences between intact and beta-blocked exercise in end-diastolic left ventricular diameter.
Details
- Title: Subtitle
- Effect of beta-adrenergic blockade on left ventricular function in exercise
- Creators
- Lawrence D HorwitzJames M AtkinsStephen J Leshin
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.227(4), pp.839-842
- DOI
- 10.1152/ajplegacy.1974.227.4.839
- PMID
- 4429132
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Language
- English
- Date published
- 10/1974
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656540402771
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