Journal article
Effect of carbon monoxide on reflex vasoconstriction in man
Journal of applied physiology (1948), Vol.32(1), pp.7-11
01/1972
DOI: 10.1152/jappl.1972.32.1.7
PMID: 4550109
Abstract
The effects of inhalation of carbon monoxide on blood flow to the forearm and hand and on reflex vascular responsiveness were observed in healthy men. Carbon monoxide inhalation causes tissue hypoxia by reducing oxygen saturation and by shifting the oxyhemoglobin dissociation curve to the left, but it does not cause a change in arterial oxygen tension. This study was done to determine whether the hypoxia induced by carbon monoxide causes an inhibition of reflex vasoconstrictor responses or whether the presence of a normal arterial oxygen tension allows preservation of vascular responses. Blood flow to the forearm and hand were measured with plethysmographs and arterial pressure was obtained by auscultation. Resting values and responses to lower body negative pressure and to application of ice to the forehead were compared at three levels of carboxyhemoglobin : 4% (control), 19y 0, and 2570. There was no evidence of stimulation of the sympathoadrenal system by carbon monoxide: heart rate was unchanged and there was no vasoconstriction in the hand. Carbon monoxide caused dilatation of vessels of the forearm and reduced the vasoconstrictor responses to lower body negative pressure and to the application of ice to the forehead. It appears that the hypoxia induced by carbon monoxide causes an inhibition of reflex vasoconstrictor responses despite the presence of normal arterial oxygen tension.
Details
- Title: Subtitle
- Effect of carbon monoxide on reflex vasoconstriction in man
- Creators
- D D HeistadR C Wheeler
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1948), Vol.32(1), pp.7-11
- Publisher
- United States
- DOI
- 10.1152/jappl.1972.32.1.7
- PMID
- 4550109
- ISSN
- 0021-8987
- eISSN
- 2691-2473
- Language
- English
- Date published
- 01/1972
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040459702771
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