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Effect of changes in airway pressure and the inspiratory volume on the fluid filtration rate and pulmonary artery pressure in isolated rabbit lungs perfused with blood and acellular solution
Journal article   Peer reviewed

Effect of changes in airway pressure and the inspiratory volume on the fluid filtration rate and pulmonary artery pressure in isolated rabbit lungs perfused with blood and acellular solution

Astrid Crespo, Eva Novoa, Daniela Urich, Humberto Trejo, Alejandro Pezzulo, Jacob I Sznajder, Fernández Livia and Roberto Sánchez-de León
Investigación clínica, Vol.47(4), pp.323-335
12/2006
PMID: 17176901

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Abstract

It has been reported that ventilation with large tidal volumes causes pulmonary edema in rats by the stimulation and release of proinflammatory mediators. Our objective was to determine the level at which volutrauma induced by changes in Airway Pressure (PAW) and Inspiratory Volume (VI) produce significant changes on the Fluid Filtration Rate (FFR) and Pulmonary Artery Pressure (PAP) in lungs perfused with blood (cellular groups) or with a buffer-albumin solution (acellular groups), with a Positive End Expiratory Pressure (PEEP) 0 or 2 cmH2O and to study the effect of a vasodilator with antiinflammatory properties (fenoterol) in blood-perfused groups. Three experimental groups were used: the cellular groups studied the effect of increased PAW and IV in isolated lungs perfused with blood and PEEP 0 and 2; the acellular groups studied the increased PAW and IV in isolated lungs perfused with a buffer-albumin solution and PEEP 0 and 2; The fenoterol group studied the effect of increased PAW and IV in isolated lungs perfused with blood + fenoterol and PEEP 2. The results show that an increase of FFR is produced earlier in acellular groups than in cellular ones and that the damage in cellular groups is microscopically and macroscopically inferior when compared to acellular groups. Fenoterol did not inhibit edema formation, and that PEEP 2, both in the cellular and the acellular groups, has a protective effect. We propose the possible existence of mediators with protective effects against the formation of pulmonary edema in the blood. These data suggest that volutrauma induced pulmonary edema has a predominantly traumatic origin when the lungs are perfused with blood.
 Rabbits Data Interpretation, Statistical Lung - pathology Fenoterol - pharmacology Filtration Adrenergic beta-Agonists - pharmacology Platelet Activating Factor - antagonists & inhibitors Positive-Pressure Respiration - adverse effects Tidal Volume Pulmonary Atelectasis - etiology Pulmonary Edema - etiology Pulmonary Artery - physiology Pulmonary Circulation Pulmonary Edema - physiopathology Animals Lung - drug effects Pulmonary Edema - prevention & control Blood Pressure - physiology Respiratory Mechanics Disease Models, Animal

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