Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2

Jose A Morcuende; Pablo Gomez; Jeffrey Stack; George Oji; James Martin; Douglas C Fredericks; Joseph A Buckwalter

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Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2

Journal article

Open access

Peer reviewed

Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2

Jose A Morcuende, Pablo Gomez, Jeffrey Stack, George Oji, James Martin, Douglas C Fredericks and Joseph A Buckwalter

The Iowa orthopaedic journal, Vol.24, pp.36-42

2004

PMCID: PMC1888415

PMID: 15296204

Appears in Diamond Open Access

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888415/View

Published (Version of record) Open Access

Abstract

Segmental bone defects are challenging clinical problems, and current surgical solutions are associated with high complication rates. In oncologic reconstructive surgery, bone healing will occur coincidently with the administration of chemotherapy to treat the underlying disease. Effective methods of graft modification or bone graft alternatives can be of great help clinically. A series of osteoinductive proteins (bone morphogenetic proteins or BMPs) has been described and shown to enhance bone formation in animal models. This study was designed to evaluate the effect of chemotherapy on bone healing enhanced by rhBMP-2. We used a critical-sized bone-defect rabbit model. Histological and radiological analysis showed that chemotherapy affects both the quantity and the quality of the bone enhanced by the addition of rhBMP-2. These results suggest that the effect of chemotherapy on bone formation could be related to inhibition in a specific pathway stimulated by the rhBMP-2.

Bone and Bones - pathology

Rabbits

Bone Morphogenetic Proteins - administration & dosage

Antibiotics, Antineoplastic - pharmacology

Bone Morphogenetic Proteins - physiology

Bone Morphogenetic Protein 2

Antineoplastic Agents - therapeutic use

Cisplatin - pharmacology

Bone and Bones - drug effects

Animals

Antibiotics, Antineoplastic - therapeutic use

Antineoplastic Agents - pharmacology

Bone Neoplasms - drug therapy

Doxorubicin - pharmacology

Transforming Growth Factor beta

Details

Title: Subtitle: Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2
Creators: Jose A Morcuende - Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. jose-morcuende@uiowa.edu
Pablo Gomez
Jeffrey Stack
George Oji
James Martin
Douglas C Fredericks
Joseph A Buckwalter
Resource Type: Journal article
Publication Details: The Iowa orthopaedic journal, Vol.24, pp.36-42
PMID: 15296204
PMCID: PMC1888415
NLM abbreviation: Iowa Orthop J
ISSN: 1541-5457
eISSN: 1555-1377
Publisher: Dept. of Orthopaedics, The University of Iowa; United States
Language: English
Date published: 2004
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Injury Prevention Research Center
Record Identifier: 9984040535902771

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