Journal article
Effect of danazol on plasma lipid and lipoprotein levels in normal women
Atherosclerosis, Vol.43(1), pp.133-137
1982
DOI: 10.1016/0021-9150(82)90105-8
PMID: 7092979
Abstract
Prior studies of lipid and lipoprotein levels alterations associated with the administration of danazol, a testosterone derivative, in patients treated for endometriosis have been conflicting. We administered danazol to 7 normal menstruating women and measured plasma lipid and lipoprotein cholesterol levels prior to and 2 months after treatment. Small, non-significant decreases in total plasma cholesterol and triglyceride levels were seen, largely due to a dramatic decline in one woman with type IV hyperlipoproteinemia. No significant change in low density or very low density lipoprotein cholesterol levels was seen. However, a marked (40%) reduction of high density lipoprotein cholesterol level in the mean was found. These findings have implications for the atherogenic potential of danazol, the treatment of hyperlipidemia, and the relationship between gonadal hormones and lipoprotein levels.
Details
- Title: Subtitle
- Effect of danazol on plasma lipid and lipoprotein levels in normal women
- Creators
- Anthony A. Luciano - University of IowaRobert B. Wallace - University of IowaBarry M. Sherman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Atherosclerosis, Vol.43(1), pp.133-137
- DOI
- 10.1016/0021-9150(82)90105-8
- PMID
- 7092979
- NLM abbreviation
- Atherosclerosis
- ISSN
- 0021-9150
- eISSN
- 1879-1484
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 1982
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363591902771
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