Effect of desensitizing agents on dentin permeability and dentin tubule occlusion

Justine L Kolker; Marcos A Vargas; Steven R Armstrong; Deborah V Dawson

doi:10.3290/j.jad.a7904

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Effect of desensitizing agents on dentin permeability and dentin tubule occlusion

Journal article

Peer reviewed

Effect of desensitizing agents on dentin permeability and dentin tubule occlusion

Justine L Kolker, Marcos A Vargas, Steven R Armstrong and Deborah V Dawson

The journal of adhesive dentistry, Vol.4(3), pp.211-221

2002

DOI: 10.3290/j.jad.a7904

PMID: 12666757

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Abstract

The aim of this study was to evaluate: 1) the effect of five dentin desensitizing agents (DDAs) on permeability using hydraulic conductance, and 2) morphological tubule changes with scanning electron microscopy (SEM). The agents tested were Seal & Protect, Gluma Desensitizer, HurriSeal, D/Sense 2, and Super Seal. Thirty extracted human molars were sectioned into 1-mm mid-coronal dentin disks. Dentin permeability was measured at baseline and after treatment using bovine serum and phosphate-buffered saline at 10 psi. Treatments were applied to the occlusal surfaces of dentin according to the manufacturer's instructions. Representatives from each group were selected for SEM observation. Kruskal-Wallis ANOVA and Tukey's post-hoc comparisons were used to evaluate differences between groups. Mean percent reduction in dentin permeability for each group: SuperSeal = 97.5 +/- 4.0, HurriSeal = 54.2 +/- 35.3, D/Sense 2 = 46.6 +/- 20.4, Gluma Desensitizer = 39.6 +/- 26.7, and Seal & Protect = 33.8 +/- 19.4. The data provided strong evidence of differences in permeability reduction among the agents (p < 0.01). Pairwise comparisons of means demonstrated that the effects of SuperSeal differed significantly from the reductions achieved using Seal & Protect, Gluma Desensitizer, and D/Sense 2. Differences in the degree and content of dentinal tubule occlusion were seen among all DDAs under SEM. Of the materials included in this in vitro study, SuperSeal may be the most beneficial when treating dentin sensitivity. The wide range of results may reflect the various approaches and chemistries used to occlude tubules.

Dentin Permeability - drug effects

Microscopy, Electron, Scanning

Dentin Sensitivity - drug therapy

Resin Cements - pharmacology

Humans

Dentin - ultrastructure

Sodium Fluoride - pharmacology

Molar

Carbonates - pharmacology

Hydrostatic Pressure

Animals

Dentin - drug effects

Analysis of Variance

Cattle

Smear Layer

Statistics, Nonparametric

Surface Properties - drug effects

Methacrylates - pharmacology

Oxalic Acid - pharmacology

Benzalkonium Compounds - pharmacology

Glutaral - pharmacology

Phosphates - pharmacology

Dentinal Fluid - physiology

Details

Title: Subtitle: Effect of desensitizing agents on dentin permeability and dentin tubule occlusion
Creators: Justine L Kolker - Department of Operative Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
Marcos A Vargas
Steven R Armstrong
Deborah V Dawson
Resource Type: Journal article
Publication Details: The journal of adhesive dentistry, Vol.4(3), pp.211-221
Publisher: Germany
DOI: 10.3290/j.jad.a7904
PMID: 12666757
ISSN: 1461-5185
Language: English
Date published: 2002
Academic Unit: Biostatistics; Pediatric Dentistry; Operative Dentistry; Family Dentistry
Record Identifier: 9984066079502771

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