Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats

Lawrence Coppey; Eric Davidson; Hanna Shevalye; Michael E Torres; Mark A Yorek

doi:10.2147/DMSO.S159071

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Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats

Journal article

Open access

Peer reviewed

Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats

Lawrence Coppey, Eric Davidson, Hanna Shevalye, Michael E Torres and Mark A Yorek

Diabetes, metabolic syndrome and obesity, Vol.11, pp.117-127

04/09/2018

DOI: 10.2147/DMSO.S159071

PMCID: PMC5898889

PMID: 29674850

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https://doi.org/10.2147/DMSO.S159071View

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Abstract

Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats. Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils. In addition, a control group fed a standard diet (4% kcal fat) and a high fat fed group (45% kcal) were maintained. The treatment period was 32 weeks. The endpoints evaluated included motor and sensory nerve conduction velocity, thermal sensitivity, innervation of sensory nerves in the cornea and skin, and vascular relaxation by epineurial arterioles. Results: Menhaden oil provided the greatest benefit for improving peripheral nerve damage caused by dietary obesity. Similar results were obtained when we examined acetylcholine-mediated vascular relaxation of epineurial arterioles of the sciatic nerve. Enriching the diets with fatty acids derived from the other oils provided minimal to partial improvements. Conclusion: These studies suggest that omega-3 polyunsaturated fatty acids derived from fish oil could be an effective treatment for neural and vascular complications associated with obesity.

fish oil

nerve conduction velocity

omega-3 polyunsaturated fatty acids

omega-6 polyunsaturated fatty acids

Original Research

peripheral neuropathy

vascular reactivity

Details

Title: Subtitle: Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
Creators: Lawrence Coppey - University of Iowa
Eric Davidson - University of Iowa
Hanna Shevalye - University of Iowa
Michael E Torres - University of Iowa
Mark A Yorek - University of Iowa
Resource Type: Journal article
Publication Details: Diabetes, metabolic syndrome and obesity, Vol.11, pp.117-127
DOI: 10.2147/DMSO.S159071
PMID: 29674850
PMCID: PMC5898889
NLM abbreviation: Diabetes Metab Syndr Obes
ISSN: 1178-7007
eISSN: 1178-7007
Publisher: Dove Medical Press
Language: English
Date published: 04/09/2018
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9984359677402771

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