Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis

W Zhang; K Chaloner; H L Tillmann; C F Williams; J T Stapleton

doi:10.1111/j.1468-1293.2006.00366.x

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Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis

Journal article

Peer reviewed

Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis

W Zhang, K Chaloner, H L Tillmann, C F Williams and J T Stapleton

HIV medicine, Vol.7(3), pp.173-180

04/2006

DOI: 10.1111/j.1468-1293.2006.00366.x

PMID: 16494631

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Abstract

To conduct a meta-analysis to synthesize the evidence regarding the effect of co-infection with GB virus C (GBV-C) on survival of HIV-infected individuals, and to estimate the effect. A Bayesian meta-analysis was conducted to synthesize evidence from eligible studies. Prospective survival studies of HIV-1-infected individuals, with outcome defined as time from baseline to all-cause death, were included and classified by whether GBV-C status was determined in early or late HIV disease. The primary measure was the hazard ratio (HR) of death for HIV-infected individuals with GBV-C infection versus those without GBV-C infection. Eleven studies from eight publications met the inclusion criteria. For studies with GBV-C status measured 2 years or less after HIV seroconversion (912 subjects), the combined HR was 0.88 [95% credible interval (CI) 0.30, 1.50]. For studies with GBV-C status measured more than 2 years after HIV seroconversion (1294 subjects), the combined HR was 0.41 (95% CI 0.23, 0.69). No conclusive evidence was found of an association between survival and GBV-C infection early in HIV disease. However, when GBV-C infection was present later in HIV disease, a significant reduction in the hazard for mortality was observed for those with co-infection. Potential explanations for this difference include a non-proportional benefit of GBV-C over time, possibly related to clearance of GBV-C infection early in HIV disease. The timing of GBV-C infection appears to account for the contradictory results of studies on the effect of GBV-C coinfection on survival of HIV-infected people.

HIV-1

HIV Seropositivity

Viremia

HIV Infections - virology

Humans

Proportional Hazards Models

GB virus C

Male

Survival Rate

Viral Load

Flaviviridae Infections - virology

Time Factors

Hepatitis, Viral, Human - virology

Bayes Theorem

Flaviviridae Infections - mortality

Adult

Female

HIV Infections - mortality

Hepatitis, Viral, Human - mortality

Details

Title: Subtitle: Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis
Creators: W Zhang - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
K Chaloner
H L Tillmann
C F Williams
J T Stapleton
Resource Type: Journal article
Publication Details: HIV medicine, Vol.7(3), pp.173-180
DOI: 10.1111/j.1468-1293.2006.00366.x
PMID: 16494631
NLM abbreviation: HIV Med
ISSN: 1464-2662
eISSN: 1468-1293
Grant note: 5-M01-RR-00052 / NCRR NIH HHS M01-RR00071 / NCRR NIH HHS MO1-RR00083 / NCRR NIH HHS R01 058740 / PHS HHS AI 058740 / NIAID NIH HHS U01-AI-35040 / NIAID NIH HHS U01-AI-37613 / NIAID NIH HHS U01-HD32632 / NICHD NIH HHS U01-AI-35039 / NIAID NIH HHS M01-RR00079 / NCRR NIH HHS U01-AI-35043 / NIAID NIH HHS U01-AI42590 / NIAID NIH HHS U01-AI-37984 / NIAID NIH HHS U01-34994 / PHS HHS U01-AI31834 / NIAID NIH HHS U01-AI-35042 / NIAID NIH HHS U01-AI34993 / NIAID NIH HHS U01-AI35004 / NIAID NIH HHS
Language: English
Date published: 04/2006
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094492102771

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