Journal article
Effect of endothelin on production of cerebrospinal fluid in rabbits
Stroke (1970), Vol.23(4), pp.560-563
04/1992
DOI: 10.1161/01.STR.23.4.560
PMID: 1561689
Abstract
Endothelin is a potent vasoconstrictor in several tissues, including the choroid plexus. The goal of this study was to determine whether endothelin affects the production of cerebrospinal fluid.
Ventriculocisternal perfusion was used to measure the production of cerebrospinal fluid in anesthetized rabbits. Changes in production of cerebrospinal fluid were examined in response to vehicle, intravenous endothelin (alone and in the presence of indomethacin), and intraventricular endothelin.
Under control conditions, the reduction in production of cerebrospinal fluid in response to endothelin administered intravenously was only modestly greater than that during infusion of vehicle. Because endothelin releases cyclooxygenase products that attenuate the direct effects of endothelin in several tissues, effects of endothelin on the production of cerebrospinal fluid were also examined after inhibition of cyclooxygenase. Production of cerebrospinal fluid in response to 1 micrograms/kg i.v. endothelin was reduced more in animals treated with indomethacin than in untreated animals (-34 +/- 7% [mean +/- SEM] versus -14 +/- 6%, p less than 0.05). Thus, effects of endothelin on the production of cerebrospinal fluid are attenuated by cyclooxygenase products. Finally, responses to intraventricular endothelin were examined. Intraventricular endothelin produced a modest, but significant, reduction in the production of cerebrospinal fluid.
In summary, endothelin may play a role in regulation of the brain fluid balance by affecting the rate of production of cerebrospinal fluid, and this effect is modulated by cyclooxygenase products.
Details
- Title: Subtitle
- Effect of endothelin on production of cerebrospinal fluid in rabbits
- Creators
- K A Schalk - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242F M FaraciD D Heistad
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.23(4), pp.560-563
- Publisher
- United States
- DOI
- 10.1161/01.STR.23.4.560
- PMID
- 1561689
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Grant note
- NS 24621 / NINDS NIH HHS HL 14388 / NHLBI NIH HHS HL 16066 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/1992
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040219102771
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