Journal article
Effect of endotoxin on canine colonic motility and transit
Journal of gastrointestinal surgery, Vol.2(4), pp.391-398
08/1998
DOI: 10.1016/S1091-255X(98)80080-2
PMID: 9841998
Abstract
Diarrhea is a common problem in patients who have episodes of sepsis and are beingfed enterally. Endotoxemia results in gastrointestinal motor dysfunction characterized by slowed gastric emptying and rapid intestinal transit; however, the effect of endotoxin on colonic motility is unknown. The aim of our study was to determine the effects of a single sublethal dose of endotoxin on colonic motility and transit. Seven dogs underwent construction of a 50 cm colonic Thiry-Vella fistula. Five manometry catheters were sewn into the colonic lumen at 8 cm intervals along the fistula. Following recovery, the fistula was perfused with an isotonic solution at 2.9 ml/min, and fasting and postprandial colonic motility was determined. Liquid transit was assessed by bolus ofa nonabsorbable marker instilled into the proximal end of the Thiry-Vella fistula. Recordings of gastrointestinal contractile activity were made digitally to determine contractile frequencies and motility indexes. Following completion of the baseline studies, each dog was given a single dose ofE. coli lipopolysaccharide, 200 γg/kg intravenously, and studies were repeated daily for the next 3 days. Endotoxin doubled the fasting colonic contractile frequency on postendotoxin day 1 and also increased motility indexes on that same day. Fasting motility indexes and contractile activity were decreased on postendotoxin days 2 and 3. The postprandial frequency of contractions and motility indexes were decreased on postendotoxin day 3. Fasting colonic liquid transit was rapid on postendotoxin day 1, whereas postprandial liquid transit was rapid on both postendotoxin days 1 and 2. Endotoxin temporarily speeds liquid transit and increases both the frequency and strength of colonic contractions. These effects may contribute to the diarrhea that occurs during episodes of sepsis.
Details
- Title: Subtitle
- Effect of endotoxin on canine colonic motility and transit
- Creators
- Stephen Spates - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City IowaJoseph Cullen - University of Iowa Hospitals and Clinics 4622 JCP 52242 Iowa City IAKimberly Ephgrave - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City IowaMarilyn Hinkhouse - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of gastrointestinal surgery, Vol.2(4), pp.391-398
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- DOI
- 10.1016/S1091-255X(98)80080-2
- PMID
- 9841998
- ISSN
- 1091-255X
- eISSN
- 1873-4626
- Language
- English
- Date published
- 08/1998
- Academic Unit
- Surgery; Radiation Oncology
- Record Identifier
- 9984051534302771
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