Journal article
Effect of flordipine on cerebral blood flow
The Journal of pharmacology and experimental therapeutics, Vol.235(1), pp.92-97
1985
DOI: 10.1016/S0022-3565(25)23906-4
PMID: 4045730
Abstract
The goal of this study was to determine effects of flordipine (REV 2609), a calcium channel blocker, on blood flow to brain and other organs. Blood flow was measured with microspheres during i.v. infusion of 0.5 to 2.0 mg/kg of flordipine in anesthetized and awake rabbits. In anesthetized rabbits, flordipine (0.5 mg/kg) increased cerebral blood flow by 50%, despite a small decrease in arterial pressure, with no increase in blood flow to skeletal muscle, bowel or kidney. Higher doses of flordipine produced 2- to 3-fold increases in cerebral and myocardial blood flow, marked increases in flow to skeletal muscle, but no increase in blood flow to bowel or kidney. Blood flow remained elevated 1 hr after stopping infusion of flordipine. The increase in cerebral blood flow was not associated with an increase in cerebral oxygen consumption. In awake rabbits, flordipine also produced a dose-related increase in cerebral, myocardial and skeletal muscle flood flow, with no increase in flow to bowel or kidney. Thus, flordipine produces a relatively selective increase in cerebral and myocardial blood flow. The increase in cerebral blood flow is the result of a direct vasodilator effect of flordipine and is not secondary to an increase in cerebral metabolism.
Details
- Title: Subtitle
- Effect of flordipine on cerebral blood flow
- Creators
- William G Mayhan - Univ. Iowa, coll. medicineDonald D Heistad - Univ. Iowa, coll. medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of pharmacology and experimental therapeutics, Vol.235(1), pp.92-97
- Publisher
- American Society for Pharmacology and Experimental Therapeutics; Bethesda, MD
- DOI
- 10.1016/S0022-3565(25)23906-4
- PMID
- 4045730
- ISSN
- 0022-3565
- eISSN
- 1521-0103
- Language
- English
- Date published
- 1985
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040490402771
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