Journal article
Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery
Molecular pharmaceutics, Vol.10(6), pp.2331-2339
06/03/2013
DOI: 10.1021/mp3007083
PMCID: PMC3718312
PMID: 23590208
Abstract
Microneedle-enhanced transdermal drug delivery greatly improves the subset of pharmacologically active molecules that can be transported across the skin. Formulation pH plays an important role in all drug delivery systems; however, for transdermal delivery it becomes specifically significant since a wide range of pH values can be exploited for patch formulation as long as it does not lead to skin irritation or sensitization issues. Wound healing literature has shown significant pH effects on barrier recovery. Stability and solubility of the drug, and thus transport across skin are all affected by formulation pH. The current study examined the role of ionization state of the drug naltrexone on transdermal flux and permeability across microneedle treated skin, as compared to intact skin. Impedance spectroscopy was done in pigs
in vivo
to assess the role of formulation pH on the rate of micropore closure under the influence of three different pH conditions. The data indicated that while there was significant advantage of using a lower pH formulation in terms of total transport across microneedle treated skin, the pH however did not have any significant effect on the rate of micropore closure beyond the first 24 hours.
Details
- Title: Subtitle
- Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery
- Creators
- Priyanka Ghosh - Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USANicole K Brogden - Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USAAudra L Stinchcomb - Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA
- Resource Type
- Journal article
- Publication Details
- Molecular pharmaceutics, Vol.10(6), pp.2331-2339
- DOI
- 10.1021/mp3007083
- PMID
- 23590208
- PMCID
- PMC3718312
- NLM abbreviation
- Mol Pharm
- ISSN
- 1543-8384
- eISSN
- 1543-8392
- Grant note
- R42 DA032191 || DA / National Institute on Drug Abuse : NIDA R21 DA031439 || DA / National Institute on Drug Abuse : NIDA R43 DA032161 || DA / National Institute on Drug Abuse : NIDA R01 DA013425 || DA / National Institute on Drug Abuse : NIDA
- Language
- English
- Date published
- 06/03/2013
- Academic Unit
- Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984025310602771
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