Journal article
Effect of furosemide on the renal excretion of digoxin
Clinical pharmacology and therapeutics, Vol.20(4), pp.395-400
10/1976
DOI: 10.1002/cpt1976204395
PMID: 975715
Abstract
Digoxin serum and urine levels were determined by radioimmunoassay in 6 subjects (4 patients with heart disease and 2 volunteers without heart disease) who had been maintained on oral digoxin (0.25 or 0.5 mg daily). Observations were made during a 3‐day control period and then during 8 days of concomitant digoxin and oral furosemide (40 mg daily) therapy. Serum digoxin levels determined 10 and 24 hr after each dose of digoxin averaged 1.2 ± 0.1 ng/ml (M ± SE) during control and 1.3 ± 0.1 during the last 3 days on digoxin and furosemide. The daily urinary excretion of digoxin averaged 51 ± 6% of the oral dose during control and 52 ± 6 during the entire period of furosemide administration. The renal clearance of digoxin and creatinine averaged 94 ± 7 and 87 ± 11 ml/min, respectively, during control; corresponding values were 88 ± 8 and 85 ± 9 for urine collections demonstrating a distinct diuretic effect of furosemide and 87 ± 8 and 75 ± 10 for urine collections not demonstrating such an effect during diuretic therapy. The results suggest that the diuretic effect of furosemide does not significantly affect the excretion of digoxin.
Details
- Title: Subtitle
- Effect of furosemide on the renal excretion of digoxin
- Creators
- Donald D BrownJohn C DormoisGeorge N AbrahamKathy LewisKeith Dixon
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.20(4), pp.395-400
- DOI
- 10.1002/cpt1976204395
- PMID
- 975715
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 6
- Language
- English
- Date published
- 10/1976
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094626302771
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