Journal article
Effect of helicopter transport on neurological outcomes in a mouse model of embolic stroke with reperfusion: AIR-MICE pilot study
International journal of stroke, Vol.10 Suppl A100(SA100), pp.119-124
10/2015
DOI: 10.1111/ijs.12619
PMID: 26376603
Abstract
Patients often suffer a stroke at a significant distance from a center capable of delivering endovascular therapy, thus requiring rapid transport by helicopter emergency medical services while receiving a recombinant tissue plasminogen activator infusion that was initiated locally. But little is known about how a helicopter flight may impact the safety and efficacy of recombinant tissue plasminogen activator-induced reperfusion and patient outcomes.
To establish a new animal method to address with fidelity the safety and overall effect of helicopter emergency medical services during thrombolysis.
Prospective randomized open blinded end-point study of an actual helicopter flight exposure. Adult C57BL/6 male mice were treated with a 10 mg/kg recombinant tissue plasminogen activator infusion two-hours after an embolic middle cerebral artery occlusion. Mice were randomized in pairs to simultaneously receive the infusion during a local helicopter flight or in a ground hangar.
Eighteen mice (nine pairs) were analyzed. The paired t-test analysis showed nonsignificant smaller infarction volumes in the helicopter-assigned animals (mean pair difference 33 mm(3) , P = 0·33). The amount of hemorrhagic transformation between the helicopter and ground groups was 4·08 vs. 4·56 μl, respectively (paired t-test, P = 0·45).
This study shows that helicopter emergency medical services do not have an inherent adverse effect on outcome in a mouse model of ischemic stroke with reperfusion. These results endorse the safety of the practice of using helicopter emergency medical services in stroke patients. The observed potential synergistic effect of helicopter-induced factors, such as vibration and changes in altitude, with reperfusion merits further exploration in animal experimental models and in stroke patients.
Details
- Title: Subtitle
- Effect of helicopter transport on neurological outcomes in a mouse model of embolic stroke with reperfusion: AIR-MICE pilot study
- Creators
- Enrique C Leira - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USAAsgar Zaheer - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USAThomas Schnell - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USAJames C Torner - Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USAHeena M Olalde - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USAAndrew A Pieper - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USASantiago Ortega-Gutierrez - Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USANandakumar Nagaraja - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USANancy L Marks - Office of the Institutional Animal Care and Use, University of Iowa, Iowa City, IA, USAHarold P Adams Jr - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- International journal of stroke, Vol.10 Suppl A100(SA100), pp.119-124
- DOI
- 10.1111/ijs.12619
- PMID
- 26376603
- NLM abbreviation
- Int J Stroke
- ISSN
- 1747-4930
- eISSN
- 1747-4949
- Publisher
- United States
- Grant note
- name: Shirley Stoppelmoor Stroke Research Fund
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Neurology; Electrical and Computer Engineering; Psychiatry; Surgery; Injury Prevention Research Center; Radiology; Occupational and Environmental Health; Epidemiology; Iowa Neuroscience Institute; Industrial and Systems Engineering; Radiation Oncology; Public Policy Center (Archive); Neurosurgery
- Record Identifier
- 9983995177602771
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