Journal article
Effect of high frequency oscillatory ventilation on fluid filtration rate in isolated perfused rabbit lungs
Intensive care medicine, Vol.15(3), pp.155-159
1989
DOI: 10.1007/BF01058566
PMID: 2738219
Abstract
We have studied the effect of changing ventilatory frequency (VF) of high frequency oscillatory ventilation (HFOV) on fluid filtration rate (FFR) in twelve isolated rabbit lungs perfused at constant blood flow. Mean pulmonary artery pressure (Ppa), mean left atrial pressure (Pla), airway pressure (Paw), pulmonary vascular resistance (PVR), pH, O2 and CO2 partial arterial pressures (PaO2 and PaCO2) and plasma colloid osmotic pressure (COP), were measured. We ventilated the lungs with a modified Bird Mark 7 ventilator which could achieve HFOV (range 5-30 Hertz). In each experiment VF was randomly varied on ten different occasions, maintaining each variation for ten minutes. The first group of six rabbits was ventilated under normal haemodynamic conditions. The other six rabbits were ventilated after the production of hydrostatic lung oedema. Blood gas exchange in both groups of rabbits was satisfactory. There was no statistically significant correlation between VF and FFR. We conclude that variations in VF using HFOV does not alter lung fluid balance in normal and in hydrostatic oedema rabbit lungs.
Details
- Title: Subtitle
- Effect of high frequency oscillatory ventilation on fluid filtration rate in isolated perfused rabbit lungs
- Creators
- R MARTINEZ-RUIZ - Univ. cent. Venezuela, fac. medicine, respiratory physiology unit, Caracas 105, VenezuelaJ ZABNER - Univ. cent. Venezuela, fac. medicine, respiratory physiology unit, Caracas 105, VenezuelaS ANGELI - Univ. cent. Venezuela, fac. medicine, respiratory physiology unit, Caracas 105, VenezuelaR SANCHEZ DE LEON - Univ. cent. Venezuela, fac. medicine, respiratory physiology unit, Caracas 105, Venezuela
- Resource Type
- Journal article
- Publication Details
- Intensive care medicine, Vol.15(3), pp.155-159
- Publisher
- Springer
- DOI
- 10.1007/BF01058566
- PMID
- 2738219
- ISSN
- 0342-4642
- eISSN
- 1432-1238
- Language
- English
- Date published
- 1989
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094728902771
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