Journal article
Effect of high-frequency positive-pressure ventilation on halothane ablation of hypoxic pulmonary vasoconstriction
Critical care medicine, Vol.13(8), pp.641-645
08/1985
DOI: 10.1097/00003246-198508000-00006
PMID: 3893888
Abstract
High-frequency positive-pressure ventilation (HFPPV) was compared to intermittent positive-pressure ventilation (IPPV) during unilateral atelectasis with and without halothane anesthesia. Dogs with electromagnetic flow probes chronically implanted on their main (Qt) and left (Qt) pulmonary arteries were ventilated via Carlenʼs dual-lumen endotracheal tubes. In eight closed-chest dogs, about 43% of the cardiac output perfused the left lung during bilateral ventilation by either a Harvard animal respirator (IPPV) or a Healthdyne model 300 high-frequency ventilator (HFPPV). Unilateral atelectasis decreased blood flow (Qt/Qt) to that lung. Q1/Qt was 19 ± 1% with HFPPV during leftlung atelectasis and right-lung ventilation, compared to 32 ± 1% with unilateral IPPV. This suggests that HFPPV permits stronger hypoxic pulmonary vasoconstriction. Addition of 1% halothane increased blood flow to the atelectatic left lung during unilateral ventilation with IPPV but not with HFPPV. This suggests that halothane decreases the effects of hypoxic pulmonary vasoconstriction during conventional ventilation but not during HFPPV.
Details
- Title: Subtitle
- Effect of high-frequency positive-pressure ventilation on halothane ablation of hypoxic pulmonary vasoconstriction
- Creators
- STANLEY HALL - Department of Anesthesiology, Charity Hospital (Dr. Hall), and the Department of Physiology. Louisiana State University Medical Center (Dr. Chapleau, Mr. Cairo, and Dr. Levitzky). New Orleans, LAMARK CHAPLEAUJIMMY CAIROMICHAEL LEVITZKY
- Resource Type
- Journal article
- Publication Details
- Critical care medicine, Vol.13(8), pp.641-645
- Publisher
- Williams & Wilkins
- DOI
- 10.1097/00003246-198508000-00006
- PMID
- 3893888
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Language
- English
- Date published
- 08/1985
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025578302771
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