Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes

Stephen K Van Den Eeden; Aruna V Sarma; Brandy N Rutledge; Patricia A Cleary; John W Kusek; Leroy M Nyberg; Kevin T McVary; Hunter Wessells; Diabetes Control and Complications Trial/Epidemiology of Diabetes Research Group

doi:10.2337/dc07-2375

Back

Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes

Journal article

Open access

Peer reviewed

Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes

Stephen K Van Den Eeden, Aruna V Sarma, Brandy N Rutledge, Patricia A Cleary, John W Kusek, Leroy M Nyberg, Kevin T McVary, Hunter Wessells and Diabetes Control and Complications Trial/Epidemiology of Diabetes Research Group

Diabetes Care, Vol.32(4), pp.664-670

2009

DOI: 10.2337/dc07-2375

PMCID: PMC2660483

PMID: 19171725

Files and links (1)

url

https://doi.org/10.2337/dc07-2375View

Published (Version of record) Open Access

Abstract

OBJECTIVE: Although diabetes is known to result in lower urinary tract symptoms (LUTS) in men, it remains unclear if glycemic control can mitigate urinary symptoms. We studied how diabetic characteristics are related to LUTS in the men who completed the urological assessment component (UroEDIC) of the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study of the Diabetes Control and Complications Trial (DCCT) participants.RESEARCH DESIGN AND METHODS: Study participants were men who completed the UroEDIC questionnaire at the year 10 DCCT/EDIC follow-up examination, which included data on genitourinary tract function and the American Urological Association Symptom Index (AUASI). Analyses were conducted to assess how treatment arm and diabetes characteristics were associated with LUTS using logistic regression.RESULTS: Of the 591 men who completed the AUASI questions, nearly 20% (n = 115) had AUASI scores in the moderate to severe category for LUTS (AUASI score >or=8). No associations were observed between LUTS and treatment arm, or A1C levels at the DCCT baseline or end-of-study or at the year 10 EDIC (UroEDIC) examination. Of the diabetes complications studied, only erectile dysfunction at the UroEDIC examination was associated with LUTS.CONCLUSIONS: These data from the UroEDIC cohort do not support the assumption that intensive glycemic control results in decreased lower urinary tract symptom severity in men with type 1 diabetes. This result may be due to a true lack of effect, or it may be due to other factors, for example, the relatively young age of the cohort.

Details

Title: Subtitle: Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes
Creators: Stephen K Van Den Eeden
Aruna V Sarma
Brandy N Rutledge
Patricia A Cleary
John W Kusek
Leroy M Nyberg
Kevin T McVary
Hunter Wessells
Diabetes Control and Complications Trial/Epidemiology of Diabetes Research Group
Contributors: H Culver Boldt (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
Resource Type: Journal article
Publication Details: Diabetes Care, Vol.32(4), pp.664-670
DOI: 10.2337/dc07-2375
PMID: 19171725
PMCID: PMC2660483
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Language: English
Date published: 2009
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979918702771

Metrics

21 Record Views

52 Times Cited - Web of Science