Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder

Taku Saito; Gen Shinozaki; Minori Koga; Masaaki Tanichi; Shogo Takeshita; Ryuichi Nakagawa; Masanori Nagamine; Hyunkeun R Cho; Yuji Morimoto; Yasushi Kobayashi; Aihide Yoshino; Hiroyuki Toda

doi:10.1016/j.jad.2020.03.120

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Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder

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Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder

Taku Saito, Gen Shinozaki, Minori Koga, Masaaki Tanichi, Shogo Takeshita, Ryuichi Nakagawa, Masanori Nagamine, Hyunkeun R Cho, Yuji Morimoto, Yasushi Kobayashi, …

Journal of affective disorders, Vol.272, pp.417-422

07/01/2020

DOI: 10.1016/j.jad.2020.03.120

PMID: 32553385

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Abstract

•Emotional abuse/neglect was related to DNAm of FKBP5 intron 7 in the BD patients.•The interaction of this subtype and rs1360780 was related to the DNAm level.•There were no significant results in the MDD patients or the controls.•This subtype of child abuse may play an important role in the development of BD. Child abuse is a risk factor for mood disorders, and linked to decreased DNA methylation (DNAm) of FKBP5 intron 7 through interactions with the single nucleotide polymorphism (SNP) rs1360780. However, no study has investigated which specific subtypes of child abuse are related to decreased DNAm of FKBP5 intron 7 in mood disorders. We therefore aimed to examine the relationship among various subtypes of child abuse, rs1360780, and the DNAm level of FKBP5 intron 7. A total of 190 subjects (87 patients with major depressive disorder [MDD], 61 patients with bipolar disorder [BD], and 42 healthy controls) participated. The Child Abuse and Trauma Scale (CATS) was used to evaluate child abuse. Whole blood was processed for genotyping, and pyrosequencing was conducted to assess the DNAm level of FKBP5 intron 7. A multiple regression analysis was used to analyze the DNAm level as a dependent variable, and the CATS subtypes and rs1360780 were used as independent variables. Emotional abuse/neglect, one of the specific subtypes of child abuse, was related to lower DNAm of FKBP5 intron 7 interacting with rs1360780 in the BD patients. There were no significant results in the MDD patients or the controls. Since the study was limited to Japanese individuals, particularly those with MDD and BD, the findings are not generalizable. Furthermore, as child abuse was measured retrospectively, there may be recall bias. This finding indicates that a specific subtype of child abuse may play an important role in the development of BD.

DNA methylation

Bipolar disorder

CATS

Child abuse

rs1360780

FKBP5

Details

Title: Subtitle: Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder
Creators: Taku Saito - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Gen Shinozaki - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
Minori Koga - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Masaaki Tanichi - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Shogo Takeshita - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Ryuichi Nakagawa - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Masanori Nagamine - Division of Behavioral Science, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan
Hyunkeun R Cho - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
Yuji Morimoto - Department of Physiology, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Yasushi Kobayashi - Department of Anatomy and Neurobiology, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Aihide Yoshino - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Hiroyuki Toda - Department of Psychiatry, School of Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.272, pp.417-422
DOI: 10.1016/j.jad.2020.03.120
PMID: 32553385
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/501100001691, name: Japan Society for the Promotion of Science, award: JP18K07617
Language: English
Date published: 07/01/2020
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Biostatistics; Anesthesia; Neurosurgery
Record Identifier: 9984070250902771

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