Journal article
Effect of isoproterenol on regional myocardial perfusion and tissue oxygenation in acute myocardial infarction
The American heart journal, Vol.97(3), pp.339-342
03/1979
DOI: 10.1016/0002-8703(79)90433-2
PMID: 420073
Abstract
The effect of isoproterenol infusion on regional myocardial perfusion and tissue oxygenation during acute myocardial infarction was investigated in anesthetized dogs. Measurements of regional flow with radioactive microspheres and myocardial lactate and adenosine triphosphate from analysis of myocardial biopsies were compared in normal, marginal, and infarcted tissue in dogs with a ligated coronary artery. After 10 minutes of isoproterenol 0.15 μg/Kg./minute, flow was unchanged in the marginal and infarcted regions, and, although rises occurred in most dogs, changes were inconsistent in the normal regions. In the marginal regions, tissue lactate rose by 5.6 μmoles/g (97 per cent) and adenosine triphosphate fell by 2.4 μmoles/g (46 per cent) after isoproterenol. No consistent changes occurred in the normal or infarcted regions of the dogs given isoproterenol or in any regions of control dogs given saline. It is concluded that beta-adrenergic stimulation with isoproterenol increases tissue ischemia in experimental acute myocardial infarction.
Details
- Title: Subtitle
- Effect of isoproterenol on regional myocardial perfusion and tissue oxygenation in acute myocardial infarction
- Creators
- David A. Schwartz - United States Department of Veterans AffairsFrederick L. Grover - United States Department of Veterans AffairsLawrence D. Horwitz - The University of Texas Health Science Center at San Antonio
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.97(3), pp.339-342
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-8703(79)90433-2
- PMID
- 420073
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 03/1979
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656594302771
Metrics
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