Journal article
Effect of lanthanide ions on dynamic nuclear polarization enhancement and liquid-state T-1 relaxation
Magnetic resonance in medicine, Vol.68(6), pp.1949-1954
11/01/2012
DOI: 10.1002/mrm.24207
PMCID: PMC3371393
PMID: 22367680
Abstract
In the dynamic nuclear polarization process, microwave irradiation facilitates exchange of polarization from a radical's unpaired electron to nuclear spins at cryogenic temperatures, increasing polarization by >10,000. Doping samples with Gd3+ ions further increases the achievable solid-state polarization. However, on dissolution, paramagnetic lanthanide metals can be potent relaxation agents, decreasing liquid-state polarization. Here, the effects of lanthanide metals on the solid and liquid-state magnetic properties of [1-C-13]pyruvate are studied. The results show that in addition to gadolinium, holmium increases not only the achievable polarization but also the rate of polarization. Liquid-state relaxation studies found that unlike gadolinium, holmium minimally affects T1. Additionally, results reveal that linear contrast agents dissociate in pyruvic acid, greatly reducing liquid-state T1. Although macrocyclic agents do not readily dissociate, they yield lower solid-state polarization. Results indicate that polarization with free lanthanides and subsequent chelation during dissolution produces the highest polarization enhancement while minimizing liquid-state relaxation. Magn Reson Med, 2012. (c) 2012 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Effect of lanthanide ions on dynamic nuclear polarization enhancement and liquid-state T-1 relaxation
- Creators
- Jeremy W. Gordon - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonIan J. Rowland - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.68(6), pp.1949-1954
- Publisher
- Wiley
- DOI
- 10.1002/mrm.24207
- PMID
- 22367680
- PMCID
- PMC3371393
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 6
- Grant note
- P50AG033514 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P50-AG033514 / GE Healthcare, NIH-NIA P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 11/01/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984275060102771
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