Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus

William G Mayhan; Frank M Faraci; Reynold Spector; Donald D Heistad

doi:10.1152/ajpheart.1989.257.3.H834

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Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus

Journal article

Peer reviewed

Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus

William G Mayhan, Frank M Faraci, Reynold Spector and Donald D Heistad

The American journal of physiology, Vol.257(3 Pt 2), pp.H834-H838

09/1989

DOI: 10.1152/ajpheart.1989.257.3.H834

PMID: 2782440

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Abstract

The purpose of this study was to examine effects of leukotriene D4 on blood flow to the cerebrum and choroid plexus. Blood flow was measured with microspheres in anesthetized rabbits. Under control conditions, blood flow to the cerebrum was 37 +/- 4 ml. min-1.100 g-1 (mean +/- SE) and blood flow to the choroid plexus was 428 +/- 52 ml.min-1.100 g-1. Intra-atrial infusion of leukotriene D4 at 0.1 and 1.0 microgram.kg-1.min-1 did not alter blood flow to the brain or choroid plexus, but produced a 49 +/- 3% and 69 +/- 5% decrease in blood flow to the bowel. We also examined effects of intracerebroventricular administration of leukotriene D4. Intraventricular injection of 1.0 microgram of leukotriene D4 did not affect blood flow to the cerebrum or choroid plexus. In contrast, intraventricular injection of 1.0 microgram of angiotensin II produced a 42 +/- 4% decrease in blood flow to the choroid plexus. In summary, neither intravascular nor intraventricular administration of leukotriene D4 affects blood flow to the brain or choroid plexus.

Rabbits

Angiotensin II - pharmacology

Choroid Plexus - blood supply

Injections

Animals

Regional Blood Flow - drug effects

Cerebrovascular Circulation - drug effects

Heart Atria

Injections, Intraventricular

SRS-A - pharmacology

Details

Title: Subtitle: Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus
Creators: William G Mayhan - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
Frank M Faraci
Reynold Spector
Donald D Heistad
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.257(3 Pt 2), pp.H834-H838
Publisher: United States
DOI: 10.1152/ajpheart.1989.257.3.H834
PMID: 2782440
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-02124 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS HL-35940 / NHLBI NIH HHS
Language: English
Date published: 09/1989
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040206502771

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