Journal article
Effect of local sympathetic blockade on forearm blood flow and glucose uptake during hypoglycemia
Metabolism, clinical and experimental, Vol.48(12), pp.1575-1583
1999
DOI: 10.1016/S0026-0495(99)90248-2
PMID: 10599991
Abstract
During hypoglycemia, hepatic glucose production increases and peripheral glucose utilization decreases. Systemic β-adrenergic blockade during hypoglycemia increases peripheral glucose utilization. To explore the local effects of increased α- and β-adrenergic activity on skeletal muscle glucose utilization, we measured arterial and venous plasma glucose concentrations, forearm blood flow (FBF), and forearm glucose uptake (FGU) during a hyperinsulinemic (40 mU/m
2/min) stepped-hypoglycemic clamp with intrabrachial artery infusion of saline, phentolamine, propranolol, or combined phentolamine and propranolol. A control study was also performed with a euglycemic clamp and intraarterial saline. During hypoglycemia with saline and phentolamine, there were significant increases in FBF (130% ± 38% and 180% ± 35%, respectively) and FGU (120% ± 51% and 230% ± 150%, respectively). During hypoglycemia with propranolol and phentolamine + propranolol, FBF remained constant. FGU during hypoglycemia with propranolol was not different versus hypoglycemia with saline. No differences were found in these studies for forearm lactate output (FLO) or venous free fatty acid concentrations. These results demonstrate that local, as opposed to systemic, blockade during hypoglycemia does not alter peripheral glucose utilization.
Details
- Title: Subtitle
- Effect of local sympathetic blockade on forearm blood flow and glucose uptake during hypoglycemia
- Creators
- Robert P HoffmanChristine A SinkeyEva Tsalikian
- Resource Type
- Journal article
- Publication Details
- Metabolism, clinical and experimental, Vol.48(12), pp.1575-1583
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0026-0495(99)90248-2
- PMID
- 10599991
- ISSN
- 0026-0495
- eISSN
- 1532-8600
- Language
- English
- Date published
- 1999
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093478002771
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