Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women’s Health Initiative

S.N Rajpathak; X Xue; S Wassertheil-Smoller; L Van Horn; L Snetselaar; L.W Martin; T.E Rohan

doi:10.1016/j.numecd.2010.07.002

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Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women’s Health Initiative

Journal article

Peer reviewed

Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women’s Health Initiative

S.N Rajpathak, X Xue, S Wassertheil-Smoller, L Van Horn, L Snetselaar, L.W Martin and T.E Rohan

Nutrition, metabolism, and cardiovascular diseases, Vol.22(4), pp.337-339

04/2012

DOI: 10.1016/j.numecd.2010.07.002

PMCID: PMC3378240

PMID: 20884191

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https://www.ncbi.nlm.nih.gov/pmc/articles/3378240View

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Abstract

Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women’s Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50–79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.

Hemostatic factors

Low-fat diet

Details

Title: Subtitle: Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women’s Health Initiative
Creators: S.N Rajpathak - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
X Xue - Albert Einstein College of Medicine
S Wassertheil-Smoller - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
L Van Horn - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
L Snetselaar - Departments of Epidemiology & Medicine, University of Iowa, Iowa City, IA, USA
L.W Martin - Department of Epidemiology, George Washington University, Washington DC, USA
T.E Rohan - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Resource Type: Journal article
Publication Details: Nutrition, metabolism, and cardiovascular diseases, Vol.22(4), pp.337-339
DOI: 10.1016/j.numecd.2010.07.002
PMID: 20884191
PMCID: PMC3378240
NLM abbreviation: Nutr Metab Cardiovasc Dis
ISSN: 0939-4753
eISSN: 1590-3729
Publisher: Elsevier B.V
Language: English
Date published: 04/2012
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995117802771

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