Journal article
Effect of memory impairment on training outcomes in ACTIVE
Journal of the International Neuropsychological Society, Vol.13(6), pp.953-960
11/01/2007
DOI: 10.1017/S1355617707071512
PMCID: PMC2733239
PMID: 17942013
Abstract
Cognitive training improves mental abilities in older adults, but the trainability of persons with memory impairment is unclear. We conducted a subgroup analysis of subjects in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial to examine this issue. ACTIVE enrolled 2802 non-demented, community-dwelling adults aged 65 years and older and randomly assigned them to one of four groups: Memory training, reasoning training, speed-of-processing training, or no-contact control. For this study, participants were defined as memory-impaired if baseline Rey Auditory Verbal Learning Test (AVLT) sum recall score was 1.5 SD or more below predicted AVLT sum recall score from a regression-derived formula using age, education, ethnicity, and vocabulary from all subjects at baseline. Assessments were taken at baseline (BL), post-test, first annual (A1), and second annual (A2) follow-up. One hundred and ninety-three subjects were defined as memory-impaired and 2580 were memory-normal. Training gain as a function memory status (impaired
vs
. normal) was compared in a mixed effects model. Results indicated that memory-impaired participants failed to benefit from Memory training but did show normal training gains after reasoning and speed training. Memory function appears to mediate response to structured cognitive interventions in older adults.
Details
- Title: Subtitle
- Effect of memory impairment on training outcomes in ACTIVE
- Creators
- FREDERICK W. Unverzagt - Indiana UniversityLINDA Kasten - New England Research InstitutesKATHY E. Johnson - Indiana University – Purdue University IndianapolisGEORGE W. Rebok - Johns Hopkins UniversityMICHAEL Marsiske - University of Florida HealthKATHY MANN Koepke - National Institute of Nursing ResearchJEFFREY W. Elias - National Institute on AgingJOHN N. Morris - Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana New England Research Institutes, Watertown, Massachusetts Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana Department of Mental Health, Johns Hopkins University, Baltimore, Maryland Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida National Institute of Nursing Research, Bethesda, Maryland National Institute on Aging, Bethesda, Maryland Hebrew Senior Life, Boston, Massachusetts Department of Human Development and Family Studies, Pennsylvania State University, State College, Pennsylvania Department of Psychology, University of Alabama, Birmingham, Alabama Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana Department of Health Management and Policy, University of Iowa, Iowa City, IowaSHERRY L. Willis - Pennsylvania State UniversityKARLENE Ball - University of Alabama at BirminghamDANIEL F. Rexroth - Indiana UniversityDAVID M. Smith - Indiana UniversityFREDRIC D. Wolinsky - University of IowaSHARON L. Tennstedt - New England Research Institutes
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.13(6), pp.953-960
- DOI
- 10.1017/S1355617707071512
- PMID
- 17942013
- PMCID
- PMC2733239
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Language
- English
- Date published
- 11/01/2007
- Academic Unit
- Health Management and Policy
- Record Identifier
- 9984363621802771
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