Journal article
Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model
Free radical research, Vol.54(5), pp.311-318
05/03/2020
DOI: 10.1080/10715762.2020.1754409
PMCID: PMC7329571
PMID: 32326763
Abstract
This study sought to determine whether the addition of mitoquinone (Mito-Q) in the diet is an effective treatment for peripheral neuropathy in animal models of diet-induced obesity (pre-diabetes) and type 2 diabetes. Unlike other anti-oxidative stress compounds investigated as a treatment for peripheral neuropathy, Mito-Q specifically targets mitochondria. Although mito-Q has been shown to reduce oxidative stress generated by mitochondria there have been no studies performed of the effect of Mito-Q on peripheral neuropathy induced by diet-induced obesity or type 2 diabetes. Diet-induced obese (12 weeks after high fat diet) or type 2 diabetic rats (12 weeks of high fat diet and 4 weeks after the onset of hyperglycemia) were treated via the diet with Mito-Q (0.93 g/kg diet) for 12 weeks. Afterwards, glucose utilization, vascular reactivity of epineurial arterioles to acetylcholine and peripheral neuropathy related endpoints were examined. The addition of Mito-Q to the diets of obese and diabetic rats improved motor and/or sensory nerve conduction velocity, cornea and intraepidermal nerve fibre density, cornea sensitivity and thermal nociception. Surprisingly, treating obese and diabetic rats with Mito-Q did not improve glucose utilization or vascular reactivity by epineurial arterioles to acetylcholine. These studies imply that mitochondrial dysfunction contributes to peripheral neuropathy in animal models of pre-diabetes and late-stage type 2 diabetes. However, improvement in peripheral neuropathy following treatment with Mito-Q was not associated with improvement in glucose utilization or vascular reactivity of epineurial arterioles to acetylcholine.
Details
- Title: Subtitle
- Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model
- Creators
- Brian Fink - Iowa City VA Health Care SystemLawrence Coppey - University of IowaEric Davidson - University of IowaHanna Shevalye - University of IowaAlexander Obrosov - University of IowaPratik Rajesh Chheda - University of IowaRobert Kerns - University of IowaWilliam Sivitz - University of IowaMark Yorek - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- Free radical research, Vol.54(5), pp.311-318
- DOI
- 10.1080/10715762.2020.1754409
- PMID
- 32326763
- PMCID
- PMC7329571
- NLM abbreviation
- Free Radic Res
- ISSN
- 1071-5762
- eISSN
- 1029-2470
- Publisher
- Taylor & Francis
- Grant note
- NIH Veterans Health Administration DK107339-04; DK115256-02 / National Institute of Diabetes and Digestive and Kidney Diseases Department of Veterans Affairs RX000889-05 / Rehabilitation Research and Development Office of Research and Development
- Language
- English
- Date published
- 05/03/2020
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Medicinal and Natural Products Chemistry; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984359880402771
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