Journal article
Effect of moisture sorption on the performance of crospovidone
International journal of pharmaceutics, Vol.514(1), pp.322-331
11/30/2016
DOI: 10.1016/j.ijpharm.2016.06.022
PMID: 27863679
Abstract
Crospovidone is a commonly used tablet disintegrant. However, the synthetic disintegrant has been known to be hygroscopic and high moisture content in crospovidone used could exert deleterious effects on tablets formulated with it. The objective of this study was to elicit a better understanding between crospovidone-water interaction and its effect on disintegrant performance. Moisture sorption and desorption isotherms were obtained together with the enthalpy of immersion. Crospovidone samples stored at four relative humidities were used to formulate tablets and the resultant tablets were evaluated for their mechanical, dimensional and disintegratability attributes. Analyses of the moisture sorption isotherms indicated that externally adsorbed moisture accounted for the bulk of the total moisture content in crospovidone, with minimal amount of moisture absorbed intramolecularly. Enthalpy of immersion became less exothermic with crospovidone samples stored at increasing storage humidity. Correspondingly, improvement in disintegration time became less pronounced. This was postulated to be a consequence of premature wetting of the particle surfaces by externally adsorbed moisture. High humidity was also detrimental to tablet hardness and thickness. In conclusion, the impact of moisture sorption during storage by excipients such as crospovidone could be better understood by the appreciation of crospovidone-water interaction and its consequence on tablet quality. (C) 2016 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Effect of moisture sorption on the performance of crospovidone
- Creators
- Tze Ning Hiew - National University of SingaporeNur Atiqah Binte Johan - University Hospital of UmeåParind Mahendrakumar Desai - MIT, Novartis MIT Ctr Continuous Mfg, Dept Chem Engn, Cambridge, MA 02139 USASiang Meng Chua - Meggle Singapore, 45 Jalan Pemimpin, #06-00 Foo Wah Industrial Building, Singapore 577197, Singapore.Zhi Hui LohPaul Wan Sia Heng - National University of Singapore
- Resource Type
- Journal article
- Publication Details
- International journal of pharmaceutics, Vol.514(1), pp.322-331
- Publisher
- Elsevier
- DOI
- 10.1016/j.ijpharm.2016.06.022
- PMID
- 27863679
- ISSN
- 0378-5173
- eISSN
- 1873-3476
- Number of pages
- 10
- Grant note
- National University of Singapore Graduate Research Scholarship; National University of Singapore N-148-000-008-001 / GEA-NUS PPRL fund
- Language
- English
- Date published
- 11/30/2016
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984366041302771
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