Journal article
Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy
Multiple sclerosis, Vol.7(3), pp.185-188
06/2001
DOI: 10.1177/135245850100700309
PMID: 11475443
Abstract
Fourteen consecutive clinically definite relapsing-remitting multiple sclerosis (MS) patients were treated with monthly intravenous cyclophosphamide (CTX) for 6 months. All had experienced severe clinical deterioration during the 12 months prior to treatment with CTX despite treatment with conventional immunomodulating agents and intravenous methylprednisolone. Treatment with CTX led to improvement and neurologic stability within 6 months which was sustained for at least 18 months after the onset of treatment with CTX. Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and are resistant to conventional therapy.
Details
- Title: Subtitle
- Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy
- Creators
- Omar A Khan - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAMarina Zvartau-Hind - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAChristina Caon - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAMoeen U Din - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAMickey Cochran - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USADeena Lisak - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAAlexandros C Tselis - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAJohn A Kamholz - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USAJames Y Garbern - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USARobert P Lisak - Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USA
- Resource Type
- Journal article
- Publication Details
- Multiple sclerosis, Vol.7(3), pp.185-188
- DOI
- 10.1177/135245850100700309
- PMID
- 11475443
- ISSN
- 1352-4585
- eISSN
- 1477-0970
- Language
- English
- Date published
- 06/2001
- Academic Unit
- Neurology; Psychiatry
- Record Identifier
- 9984020629102771
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