Journal article
Effect of neoadjuvant epirubicin and total androgen blockade on complete pathological response in patients with clinical stage T3/T4 prostate cancer
European journal of surgical oncology, Vol.34(2), pp.216-221
02/01/2008
DOI: 10.1016/j.ejso.2007.03.016
PMID: 17502132
Abstract
Aims: Most patients with stage T3-T4 prostate cancer experience disease relapse despite radiation and/or hormonal therapy, and their management remains controversial. We investigated the feasibility of, and the pathological response induced by neoadjuvant chemo-hormonal treatment in men with clinical stage T3/T4.
Methods: Fifteen patients underwent neoadjuvant therapy consisting of weekly intravenous infusions of epirubicin 30 mg/m(2) and total androgen blockade (TAB) for three months before undergoing radical prostatectomy, after which all received locoregional conformal radiotherapy (66 Gy) and then continued with TAB and three additional months of epirubicin.
Results: After neoadjuvant therapy, PSA levels decreased in all 15 patients and became undetectable in two. None of the patients achieved a complete pathological response, but a 35-75% reduction in tumour size was observed in all cases, and all the patients were able to undergo successful prostatectomy. Pathological assessments of the surgical specimens revealed negative margins in 13 patients. After a median follow-up of 34 months (range 11-62), 14 patients (93%) are still clinically and biochemically disease free. No grade 3 or 4 complications occurred.
Conclusion: This study suggests that neoadjuvant treatment with epirubicin and TAB is feasible and well tolerated in patients with clinical stage T3-T4 prostate cancer. (C) 2007 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Effect of neoadjuvant epirubicin and total androgen blockade on complete pathological response in patients with clinical stage T3/T4 prostate cancer
- Creators
- G. Francini - University of SienaL. Paolelli - University of SienaE. Francini - University of SienaA. Pascucci - University of SienaA. Manganelli - University of SienaF. Salvestrini - University of SienaR. Petrioli - University of Siena
- Resource Type
- Journal article
- Publication Details
- European journal of surgical oncology, Vol.34(2), pp.216-221
- DOI
- 10.1016/j.ejso.2007.03.016
- PMID
- 17502132
- NLM abbreviation
- Eur J Surg Oncol
- ISSN
- 0748-7983
- eISSN
- 1532-2157
- Publisher
- Elsevier
- Number of pages
- 6
- Language
- English
- Date published
- 02/01/2008
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221244102771
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