Journal article
Effect of nicardipine on basilar artery vasoactive responses after subarachnoid hemorrhage
Neurosurgery, Vol.31(4), pp.697-704
10/1992
DOI: 10.1097/00006123-199210000-00012
PMID: 1407455
Abstract
The effect of the dihydropyridine calcium antagonist, nicardipine, on the vasoactive responses of the basilar artery was investigated after subarachnoid hemorrhage (SAH). Forty-five rabbits were separated into one control group and four groups receiving SAH (nine animals each). The SAH was induced by injecting 5 ml of autologous arterial blood into the cisterna magna. SAH animals were subjected to one of the following: 1) no treatment; 2) intravenous (i.v.) saline infusion (vehicle); 3) i.v. infusion of low-dose nicardipine (0.01 mg/kg/hr), or 4) i.v. infusion of high-dose nicardipine (0.15 mg/kg/hr). The i.v. infusions were started immediately after SAH and continued for 48 hours. Serotonin (5-HT) (10(-8) to 10(-5) mol/L) was used to evoke dose-dependent vasoconstriction of isolated rings of the basilar artery 2 days after SAH. Acetylcholine (ACh) (10(-8) to 10(-4)) and adenosine-triphosphate (ATP) (10(-8) to 10(-4) mol/L) were applied after maximal contraction with 5-HT, evoke a dose-dependent vasodilatation. Compared with controls, in animals subjected to SAH serotonin caused similar or slightly larger contractions; nicardipine infusion did not decrease the amount of contraction observed after SAH. ACh and ATP caused significantly less dilatation in animals submitted to SAH than in controls. After high-dose nicardipine, ACh- and ATP-induced dilatations were significantly more pronounced (57% and 68% of initial contractile tone) than in the other animals receiving SAH (36%-39% and 45%-55%, respectively).
Details
- Title: Subtitle
- Effect of nicardipine on basilar artery vasoactive responses after subarachnoid hemorrhage
- Creators
- Alberto Pasqualin - Department of Neurological Surgery, University of Virginia Health Sciences Center, CharlottesvilleTetsuya TsukaharaNeal F KassellJames C Torner
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.31(4), pp.697-704
- DOI
- 10.1097/00006123-199210000-00012
- PMID
- 1407455
- NLM abbreviation
- Neurosurgery
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Publisher
- United States
- Language
- English
- Date published
- 10/1992
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995024402771
Metrics
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