Effect of norepinephrine on rat basilar artery in vivo

Takanari Kitazono; Frank M Faraci; Donald D Heistad

doi:10.1152/ajpheart.1993.264.1.H178

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Effect of norepinephrine on rat basilar artery in vivo

Journal article

Peer reviewed

Effect of norepinephrine on rat basilar artery in vivo

Takanari Kitazono, Frank M Faraci and Donald D Heistad

The American journal of physiology, Vol.264(1 Pt 2), pp.H178-H182

01/1993

DOI: 10.1152/ajpheart.1993.264.1.H178

PMID: 8430844

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Abstract

In anesthetized rats, we used a cranial window to examine effects of topical norepinephrine on diameter of the basilar artery in vivo. Topical application of norepinephrine increased the diameter of the basilar artery. NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, inhibited vasodilatation to acetylcholine but did not attenuate dilator responses to norepinephrine. Indomethacin also did not attenuate vasodilatation in response to norepinephrine. Dilatation of the basilar artery to norepinephrine was inhibited by propranolol and the beta 1-antagonist atenolol but not by the beta 2-antagonist butoxamine. Thus dilatation of the basilar artery in response to norepinephrine is produced by activation of beta 1-receptors and is not mediated by endothelium-derived relaxing factor or prostanoids. Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, partially inhibited vasodilatation in response to norepinephrine. Forskolin, a direct activator of adenylate cyclase, also increased the diameter of the basilar artery, and glibenclamide attenuated the dilatation. Thus dilatation of rat basilar artery in response to norepinephrine is mediated, in part, by activation of ATP-sensitive K+ channels, and activation of these K+ channels may be achieved by an adenosine 3',5'-cyclic monophosphate-dependent mechanism.

Norepinephrine - pharmacology

Basilar Artery - drug effects

Animals

Glyburide - pharmacology

Colforsin - pharmacology

Arginine - pharmacology

NG-Nitroarginine Methyl Ester

Rats

Male

Vasodilation - drug effects

Rats, Sprague-Dawley

Arginine - analogs & derivatives

Details

Title: Subtitle: Effect of norepinephrine on rat basilar artery in vivo
Creators: Takanari Kitazono - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City
Frank M Faraci
Donald D Heistad
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.264(1 Pt 2), pp.H178-H182
DOI: 10.1152/ajpheart.1993.264.1.H178
PMID: 8430844
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: United States
Grant note: HL-16066 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 01/1993
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040252102771

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