Journal article
Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver
Biochemical pharmacology, Vol.37(17), pp.3245-3249
1988
DOI: 10.1016/0006-2952(88)90634-X
PMID: 3041969
Abstract
Male Sprague-Dawley rats were fed for six weeks either a control diet containing 22% casein (C) and 5% fat (F) or a low-protein diet (6% C, 5% F) or high-lipid diet (30% C, 30% F). A group of rats received a control diet containing 50 ppm of Phenoclor DP6. Three major forms of cytochrome P-450, UT 50, BP 3a and MC 2 were purified from livers of DP6-fed rats and only two forms, UT 50 and PB 3a, were purified from control and dietary groups. The amino acid composition and the catalytic activities towards all substrates tested were only significantly modified in the purified UT 50 P-450 isozyme from rats fed the low-protein diet. The N-terminal sequence analysis shows that cytochrome P-450 UT 50 (from control group) and UT 501 (from low-protein group) are two distinct proteins.
Details
- Title: Subtitle
- Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver
- Creators
- Z Amelizad - Institute for Toxicology, University of Mainz, Federal Republic of GermanyJ.F Narbonne - Laboratoire de Toxicologie Alimentaire, Université de Bordeaux I, Avenue des Facultés, 33405 Talence Cedex, FranceC.R Wolf - Imperial Cancer Research Fund, Laboratory of Molecular Pharmacology and Drug Metabolism, Edinburgh, U.KL.W Robertson - Graduate Center for Toxicology, University of Kentucky, Lexington, U.S.AF Oesch - Institute for Toxicology, University of Mainz, Federal Republic of Germany
- Resource Type
- Journal article
- Publication Details
- Biochemical pharmacology, Vol.37(17), pp.3245-3249
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0006-2952(88)90634-X
- PMID
- 3041969
- ISSN
- 0006-2952
- eISSN
- 1873-2968
- Language
- English
- Date published
- 1988
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002457102771
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